Endothelin-1: a multifunctional molecule in cancer

Endothelin-1 is a small vasoconstrictor peptide that was first identified in 1988. Here we review the evidence implicating ET-1 in tumorigenesis. In particular, we concentrate on the role of ET-1 in mitogenesis, apoptosis, angiogenesis, tumour invasion and metastasis, and discuss the potential for e...

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Detalles Bibliográficos
Autores principales: Grant, K, Loizidou, M, Taylor, I
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377061/
https://www.ncbi.nlm.nih.gov/pubmed/12610497
http://dx.doi.org/10.1038/sj.bjc.6700750
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author Grant, K
Loizidou, M
Taylor, I
author_facet Grant, K
Loizidou, M
Taylor, I
author_sort Grant, K
collection PubMed
description Endothelin-1 is a small vasoconstrictor peptide that was first identified in 1988. Here we review the evidence implicating ET-1 in tumorigenesis. In particular, we concentrate on the role of ET-1 in mitogenesis, apoptosis, angiogenesis, tumour invasion and metastasis, and discuss the potential for endothelin-system modulation as an adjuvant therapeutic strategy.
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spelling pubmed-23770612009-09-10 Endothelin-1: a multifunctional molecule in cancer Grant, K Loizidou, M Taylor, I Br J Cancer Minireview Endothelin-1 is a small vasoconstrictor peptide that was first identified in 1988. Here we review the evidence implicating ET-1 in tumorigenesis. In particular, we concentrate on the role of ET-1 in mitogenesis, apoptosis, angiogenesis, tumour invasion and metastasis, and discuss the potential for endothelin-system modulation as an adjuvant therapeutic strategy. Nature Publishing Group 2003-01-27 2003-01-28 /pmc/articles/PMC2377061/ /pubmed/12610497 http://dx.doi.org/10.1038/sj.bjc.6700750 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Grant, K
Loizidou, M
Taylor, I
Endothelin-1: a multifunctional molecule in cancer
title Endothelin-1: a multifunctional molecule in cancer
title_full Endothelin-1: a multifunctional molecule in cancer
title_fullStr Endothelin-1: a multifunctional molecule in cancer
title_full_unstemmed Endothelin-1: a multifunctional molecule in cancer
title_short Endothelin-1: a multifunctional molecule in cancer
title_sort endothelin-1: a multifunctional molecule in cancer
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377061/
https://www.ncbi.nlm.nih.gov/pubmed/12610497
http://dx.doi.org/10.1038/sj.bjc.6700750
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