Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-κB and IκB kinase-α in human colorectal cancer epithelial cells

Cyclooxygenase-2 (COX-2) is selectively overexpressed in colorectal tumours. The mechanism of COX-2 induction is not fully understood, but requires de novo messenger RNA and protein synthesis, indicating regulation at the transcriptional level. Sequence analysis of the 5′-flanking region of the COX-...

Descripción completa

Detalles Bibliográficos
Autores principales: Charalambous, M P, Maihöfner, C, Bhambra, U, Lightfoot, T, Gooderham, N J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377108/
https://www.ncbi.nlm.nih.gov/pubmed/12771929
http://dx.doi.org/10.1038/sj.bjc.6600927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377108/
https://www.ncbi.nlm.nih.gov/pubmed/12771929
http://dx.doi.org/10.1038/sj.bjc.6600927

Ejemplares similares