Genetic alterations in the coding region of the bak gene in uterine cervical carcinoma

A significant frequency of mutations (six missense and one silent) was found, for the first time, at the coding region of the bak gene (exons 3, 4 and 6) in 42 carcinomas of the uterine cervix, while no mutations were detected in 32 non-neoplastic cervix tissues. Bak mutations were observed more fre...

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Autores principales: Wani, K M Y, Huilgol, N G, Hongyo, T, Shah, H Ryo K, Chatterjee, N, Nair, C K K, Nomura, T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377111/
https://www.ncbi.nlm.nih.gov/pubmed/12771926
http://dx.doi.org/10.1038/sj.bjc.6600944
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author Wani, K M Y
Huilgol, N G
Hongyo, T
Shah, H Ryo K
Chatterjee, N
Nair, C K K
Nomura, T
author_facet Wani, K M Y
Huilgol, N G
Hongyo, T
Shah, H Ryo K
Chatterjee, N
Nair, C K K
Nomura, T
author_sort Wani, K M Y
collection PubMed
description A significant frequency of mutations (six missense and one silent) was found, for the first time, at the coding region of the bak gene (exons 3, 4 and 6) in 42 carcinomas of the uterine cervix, while no mutations were detected in 32 non-neoplastic cervix tissues. Bak mutations were observed more frequently in the advanced stage and mutated cancer tissues were more resistant to radiotherapy, although trends were not statistically significant because of small sample size.
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spelling pubmed-23771112009-09-10 Genetic alterations in the coding region of the bak gene in uterine cervical carcinoma Wani, K M Y Huilgol, N G Hongyo, T Shah, H Ryo K Chatterjee, N Nair, C K K Nomura, T Br J Cancer Genetics and Genomics A significant frequency of mutations (six missense and one silent) was found, for the first time, at the coding region of the bak gene (exons 3, 4 and 6) in 42 carcinomas of the uterine cervix, while no mutations were detected in 32 non-neoplastic cervix tissues. Bak mutations were observed more frequently in the advanced stage and mutated cancer tissues were more resistant to radiotherapy, although trends were not statistically significant because of small sample size. Nature Publishing Group 2003-05-19 2003-05-13 /pmc/articles/PMC2377111/ /pubmed/12771926 http://dx.doi.org/10.1038/sj.bjc.6600944 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Genetics and Genomics
Wani, K M Y
Huilgol, N G
Hongyo, T
Shah, H Ryo K
Chatterjee, N
Nair, C K K
Nomura, T
Genetic alterations in the coding region of the bak gene in uterine cervical carcinoma
title Genetic alterations in the coding region of the bak gene in uterine cervical carcinoma
title_full Genetic alterations in the coding region of the bak gene in uterine cervical carcinoma
title_fullStr Genetic alterations in the coding region of the bak gene in uterine cervical carcinoma
title_full_unstemmed Genetic alterations in the coding region of the bak gene in uterine cervical carcinoma
title_short Genetic alterations in the coding region of the bak gene in uterine cervical carcinoma
title_sort genetic alterations in the coding region of the bak gene in uterine cervical carcinoma
topic Genetics and Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377111/
https://www.ncbi.nlm.nih.gov/pubmed/12771926
http://dx.doi.org/10.1038/sj.bjc.6600944
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