Cancer and the FRA3B/FHIT fragile locus: it's a HIT

The FHIT gene encompassing the most active common human chromosomal fragile region, FRA3B, was discovered in 1996 and proposed as a tumour suppressor gene for important human cancers. Seven years and more than 350 reports later, early questions concerning its tumour suppressor role have been answere...

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Detalles Bibliográficos
Autores principales: Huebner, K, Croce, C M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377116/
https://www.ncbi.nlm.nih.gov/pubmed/12771912
http://dx.doi.org/10.1038/sj.bjc.6600937
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author Huebner, K
Croce, C M
author_facet Huebner, K
Croce, C M
author_sort Huebner, K
collection PubMed
description The FHIT gene encompassing the most active common human chromosomal fragile region, FRA3B, was discovered in 1996 and proposed as a tumour suppressor gene for important human cancers. Seven years and more than 350 reports later, early questions concerning its tumour suppressor role have been answered. Recent studies on the role of Fhit loss in major types of human cancers report association with high proliferative and low apoptotic indices, node positivity, loss of mismatch repair protein, likelihood of progression and reduced survival.
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spelling pubmed-23771162009-09-10 Cancer and the FRA3B/FHIT fragile locus: it's a HIT Huebner, K Croce, C M Br J Cancer Minireview The FHIT gene encompassing the most active common human chromosomal fragile region, FRA3B, was discovered in 1996 and proposed as a tumour suppressor gene for important human cancers. Seven years and more than 350 reports later, early questions concerning its tumour suppressor role have been answered. Recent studies on the role of Fhit loss in major types of human cancers report association with high proliferative and low apoptotic indices, node positivity, loss of mismatch repair protein, likelihood of progression and reduced survival. Nature Publishing Group 2003-05-19 2003-05-13 /pmc/articles/PMC2377116/ /pubmed/12771912 http://dx.doi.org/10.1038/sj.bjc.6600937 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Huebner, K
Croce, C M
Cancer and the FRA3B/FHIT fragile locus: it's a HIT
title Cancer and the FRA3B/FHIT fragile locus: it's a HIT
title_full Cancer and the FRA3B/FHIT fragile locus: it's a HIT
title_fullStr Cancer and the FRA3B/FHIT fragile locus: it's a HIT
title_full_unstemmed Cancer and the FRA3B/FHIT fragile locus: it's a HIT
title_short Cancer and the FRA3B/FHIT fragile locus: it's a HIT
title_sort cancer and the fra3b/fhit fragile locus: it's a hit
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377116/
https://www.ncbi.nlm.nih.gov/pubmed/12771912
http://dx.doi.org/10.1038/sj.bjc.6600937
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