Cargando…

Apoptosis induction in renal cell carcinoma by TRAIL and γ-radiation is impaired by deficient caspase-9 cleavage

TNF-related apoptosis-inducing ligand (TRAIL APO-2L) is a member of the TNF family and induces apoptosis in cancer cells without affecting most non-neoplastic cells. The present investigation is focused on apoptosis induction by combined exposure to TRAIL and ionising radiation (IR) in human renal c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ramp, U, Caliskan, E, Mahotka, C, Krieg, A, Heikaus, S, Gabbert, H E, Gerharz, C D
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2003
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377130/ https://www.ncbi.nlm.nih.gov/pubmed/12771998 http://dx.doi.org/10.1038/sj.bjc.6600984

Ejemplares similares

TRAIL-β and TRAIL-γ: two novel splice variants of the human TNF-related apoptosis-inducing ligand (TRAIL) without apoptotic potential
por: Krieg, A, et al.
Publicado: (2003)

PIDDosome Expression and the Role of Caspase-2 Activation for Chemotherapy-Induced Apoptosis in RCCs
por: Heikaus, Sebastian, et al.
Publicado: (2010)

Expression of TRAIL-splice variants in gastric carcinomas: identification of TRAIL-γ as a prognostic marker
por: Krieg, Andreas, et al.
Publicado: (2013)

Disturbed balance of expression between XIAP and Smac/DIABLO during tumour progression in renal cell carcinomas
por: Yan, Y, et al.
Publicado: (2004)

HA14-1 is Able to Reconstitute the Impaired Mitochondrial Pathway of Apoptosis in Renal Cell Carcinoma Cell Lines
por: Heikaus, Sebastian, et al.
Publicado: (2008)

Deficient activation of CD95 (APO-1/ Fas)-mediated apoptosis: a potential factor of multidrug resistance in human renal cell carcinoma
por: Ramp, U, et al.
Publicado: (2000)

Induction of apoptosis in experimental human B cell lymphomas by conditional TRAIL-expressing T cells
por: Ucur, E, et al.
Publicado: (2003)

Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis
por: Duiker, E W, et al.
Publicado: (2011)

Heterogeneous response to differentiation induction with different polar compounds in a clonal rat rhabdomyosarcoma cell line (BA-HAN-1C).
por: Gerharz, C. D., et al.
Publicado: (1989)

Expression of different survivin variants in gastric carcinomas: first clues to a role of survivin-2B in tumour progression
por: Krieg, A, et al.
Publicado: (2002)

α-Tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells
por: Tomasetti, M, et al.
Publicado: (2004)

Differential response of head and neck cancer cell lines to TRAIL or Smac mimetics is associated with the cellular levels and activity of caspase-8 and caspase-10
por: Raulf, N, et al.
Publicado: (2014)

TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt
por: Szegezdi, E, et al.
Publicado: (2006)

TRAIL (TNF-related apoptosis-inducing ligand) regulates adipocyte metabolism by caspase-mediated cleavage of PPARgamma
por: Keuper, M, et al.
Publicado: (2013)

A SILAC-based Approach Identifies Substrates of Caspase-dependent Cleavage upon TRAIL-induced Apoptosis
por: Stoehr, Gabriele, et al.
Publicado: (2013)

Caspase-dependent and -independent suppression of apoptosis by monoHER in Doxorubicin treated cells
por: Bruynzeel, A M E, et al.
Publicado: (2007)

PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells
por: Maginn, E N, et al.
Publicado: (2011)

Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines
por: Mahalingam, D, et al.
Publicado: (2009)

Newly established tumourigenic primary human colon cancer cell lines are sensitive to TRAIL-induced apoptosis in vitro and in vivo
por: Oikonomou, E, et al.
Publicado: (2007)

Chromophilic renal cell carcinoma: cytomorphological and cytogenetic characterisation of four permanent cell lines.
por: Gerharz, C. D., et al.
Publicado: (1996)

Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy
por: Bouralexis, S, et al.
Publicado: (2003)

Inhibition of growth and induction of apoptosis in human breast cancer by transfection of gef gene
por: Boulaiz, H, et al.
Publicado: (2003)

Inhibition of γ-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells
por: Rasul, S, et al.
Publicado: (2009)

Differential modulation of the TRAIL receptors and the CD95 receptor in colon carcinoma cell lines
por: van Geelen, C M M, et al.
Publicado: (2003)

Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour activity in vivo
por: Bannon, J H, et al.
Publicado: (2007)

Superantigen reactive Vβ6(+) T cells induce perforin/granzyme B mediated caspase-independent apoptosis in tumour cells
por: Müerköster, S, et al.
Publicado: (2002)

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib
por: Lecis, D, et al.
Publicado: (2010)

α-Tocopheryl succinate sensitises a T lymphoma cell line to TRAIL-induced apoptosis by suppressing NF-κB activation
por: Dalen, H, et al.
Publicado: (2003)

Morphological, biochemical, and molecular biological characterization of a rat rhabdomyosarcoma cell line during differentiation induction in vitro.
por: Gerharz, C D, et al.
Publicado: (1990)

Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage
por: Ko, Hyeonseok, et al.
Publicado: (2015)

Interferon-γ suppresses S100A4 transcription independently of apoptosis or cell cycle arrest
por: Andersen, K, et al.
Publicado: (2003)

Caspase-8 mutations associated with head and neck cancer differentially retain functional properties related to TRAIL-induced apoptosis and cytokine induction
por: Cui, Zhibin, et al.
Publicado: (2021)

In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs
por: Ashley, D M, et al.
Publicado: (2008)

Induction of endothelial cell apoptosis by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid
por: Ching, L-M, et al.
Publicado: (2002)

Apollon gene silencing induces apoptosis in breast cancer cells through p53 stabilisation and caspase-3 activation
por: Lopergolo, A, et al.
Publicado: (2009)

Interactome disassembly during apoptosis occurs independent of caspase cleavage
por: Scott, Nichollas E, et al.
Publicado: (2017)

Caspase Cleavage of Gelsolin Is an Inductive Cue for Pathologic Cardiac Hypertrophy
por: Putinski, Charis, et al.
Publicado: (2018)

Caspase-mediated cleavage of the centrosomal proteins during apoptosis
por: Seo, Mi Young, et al.
Publicado: (2018)

BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma
por: Bodet, L, et al.
Publicado: (2010)

TRAIL-expressing mesenchymal stem cells kill the putative cancer stem cell population
por: Loebinger, M R, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_bhe5l4a8gdu447ed64fetar11r