Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men

We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable...

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Detalles Bibliográficos
Autores principales: Gunnell, D, Oliver, S E, Peters, T J, Donovan, J L, Persad, R, Maynard, M, Gillatt, D, Pearce, A, Hamdy, F C, Neal, D E, Holly, J M P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377147/
https://www.ncbi.nlm.nih.gov/pubmed/12771980
http://dx.doi.org/10.1038/sj.bjc.6600946
Descripción
Sumario:We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet–cancer associations.

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