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Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men

We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable...

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Autores principales: Gunnell, D, Oliver, S E, Peters, T J, Donovan, J L, Persad, R, Maynard, M, Gillatt, D, Pearce, A, Hamdy, F C, Neal, D E, Holly, J M P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377147/
https://www.ncbi.nlm.nih.gov/pubmed/12771980
http://dx.doi.org/10.1038/sj.bjc.6600946
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author Gunnell, D
Oliver, S E
Peters, T J
Donovan, J L
Persad, R
Maynard, M
Gillatt, D
Pearce, A
Hamdy, F C
Neal, D E
Holly, J M P
author_facet Gunnell, D
Oliver, S E
Peters, T J
Donovan, J L
Persad, R
Maynard, M
Gillatt, D
Pearce, A
Hamdy, F C
Neal, D E
Holly, J M P
author_sort Gunnell, D
collection PubMed
description We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet–cancer associations.
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spelling pubmed-23771472009-09-10 Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men Gunnell, D Oliver, S E Peters, T J Donovan, J L Persad, R Maynard, M Gillatt, D Pearce, A Hamdy, F C Neal, D E Holly, J M P Br J Cancer Epidemiology We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet–cancer associations. Nature Publishing Group 2003-06-02 2003-05-27 /pmc/articles/PMC2377147/ /pubmed/12771980 http://dx.doi.org/10.1038/sj.bjc.6600946 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Gunnell, D
Oliver, S E
Peters, T J
Donovan, J L
Persad, R
Maynard, M
Gillatt, D
Pearce, A
Hamdy, F C
Neal, D E
Holly, J M P
Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men
title Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men
title_full Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men
title_fullStr Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men
title_full_unstemmed Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men
title_short Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men
title_sort are diet–prostate cancer associations mediated by the igf axis? a cross-sectional analysis of diet, igf-i and igfbp-3 in healthy middle-aged men
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377147/
https://www.ncbi.nlm.nih.gov/pubmed/12771980
http://dx.doi.org/10.1038/sj.bjc.6600946
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