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Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men
We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2003
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377147/ https://www.ncbi.nlm.nih.gov/pubmed/12771980 http://dx.doi.org/10.1038/sj.bjc.6600946 |
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author | Gunnell, D Oliver, S E Peters, T J Donovan, J L Persad, R Maynard, M Gillatt, D Pearce, A Hamdy, F C Neal, D E Holly, J M P |
author_facet | Gunnell, D Oliver, S E Peters, T J Donovan, J L Persad, R Maynard, M Gillatt, D Pearce, A Hamdy, F C Neal, D E Holly, J M P |
author_sort | Gunnell, D |
collection | PubMed |
description | We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet–cancer associations. |
format | Text |
id | pubmed-2377147 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23771472009-09-10 Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men Gunnell, D Oliver, S E Peters, T J Donovan, J L Persad, R Maynard, M Gillatt, D Pearce, A Hamdy, F C Neal, D E Holly, J M P Br J Cancer Epidemiology We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet–cancer associations. Nature Publishing Group 2003-06-02 2003-05-27 /pmc/articles/PMC2377147/ /pubmed/12771980 http://dx.doi.org/10.1038/sj.bjc.6600946 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Epidemiology Gunnell, D Oliver, S E Peters, T J Donovan, J L Persad, R Maynard, M Gillatt, D Pearce, A Hamdy, F C Neal, D E Holly, J M P Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men |
title | Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men |
title_full | Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men |
title_fullStr | Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men |
title_full_unstemmed | Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men |
title_short | Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men |
title_sort | are diet–prostate cancer associations mediated by the igf axis? a cross-sectional analysis of diet, igf-i and igfbp-3 in healthy middle-aged men |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377147/ https://www.ncbi.nlm.nih.gov/pubmed/12771980 http://dx.doi.org/10.1038/sj.bjc.6600946 |
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