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Nuclear export inhibitor leptomycin B induces the appearance of novel forms of human Mdm2 protein

The nuclear export inhibitor leptomycin B (LMB) prevents the export of proteins from the nucleus to the cytoplasm, protects p53 from Mdm2-mediated degradation and is a very potent inducer of the p53 transcriptional activity. Here we suggest that LMB can also interfere with the degradation of human M...

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Detalles Bibliográficos
Autores principales:	Menéndez, S, Higgins, M, Berkson, R G, Edling, C, Lane, D P, Laín, S
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2003
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377168/ https://www.ncbi.nlm.nih.gov/pubmed/12592381 http://dx.doi.org/10.1038/sj.bjc.6600752

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