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Particulate debris from a titanium metal prosthesis induces genomic instability in primary human fibroblast cells

Previous studies detected both lethal and cumulative chromosomal aberrations in bone marrow and peripheral blood of patients with worn hip and knee replacements. This study shows that wear debris from a worn titanium metal on high-density polyethylene hip replacement also produces chromosomal instab...

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Autores principales: Coen, N, Kadhim, M A, Wright, E G, Case, C P, Mothersill, C E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377169/
https://www.ncbi.nlm.nih.gov/pubmed/12592368
http://dx.doi.org/10.1038/sj.bjc.6600758
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author Coen, N
Kadhim, M A
Wright, E G
Case, C P
Mothersill, C E
author_facet Coen, N
Kadhim, M A
Wright, E G
Case, C P
Mothersill, C E
author_sort Coen, N
collection PubMed
description Previous studies detected both lethal and cumulative chromosomal aberrations in bone marrow and peripheral blood of patients with worn hip and knee replacements. This study shows that wear debris from a worn titanium metal on high-density polyethylene hip replacement also produces chromosomal instability and reproductive failure in cell culture. The progeny of these treated cells also displayed chromosomal instability, mainly consisting of chromatid breaks and minutes, and reproductive failure as determined by clonogenic survival many generations postexposure. These delayed effects are similar to those caused by the heavy metals cadmium and nickel and to those seen for low-dose radiation. These findings may have important implications with regard to the long-term risks of joint replacement surgery. This highlights the need for long-term epidemiological studies of patients with surgical implants.
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spelling pubmed-23771692009-09-10 Particulate debris from a titanium metal prosthesis induces genomic instability in primary human fibroblast cells Coen, N Kadhim, M A Wright, E G Case, C P Mothersill, C E Br J Cancer Molecular and Cellular Pathology Previous studies detected both lethal and cumulative chromosomal aberrations in bone marrow and peripheral blood of patients with worn hip and knee replacements. This study shows that wear debris from a worn titanium metal on high-density polyethylene hip replacement also produces chromosomal instability and reproductive failure in cell culture. The progeny of these treated cells also displayed chromosomal instability, mainly consisting of chromatid breaks and minutes, and reproductive failure as determined by clonogenic survival many generations postexposure. These delayed effects are similar to those caused by the heavy metals cadmium and nickel and to those seen for low-dose radiation. These findings may have important implications with regard to the long-term risks of joint replacement surgery. This highlights the need for long-term epidemiological studies of patients with surgical implants. Nature Publishing Group 2003-02-24 2003-02-18 /pmc/articles/PMC2377169/ /pubmed/12592368 http://dx.doi.org/10.1038/sj.bjc.6600758 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Coen, N
Kadhim, M A
Wright, E G
Case, C P
Mothersill, C E
Particulate debris from a titanium metal prosthesis induces genomic instability in primary human fibroblast cells
title Particulate debris from a titanium metal prosthesis induces genomic instability in primary human fibroblast cells
title_full Particulate debris from a titanium metal prosthesis induces genomic instability in primary human fibroblast cells
title_fullStr Particulate debris from a titanium metal prosthesis induces genomic instability in primary human fibroblast cells
title_full_unstemmed Particulate debris from a titanium metal prosthesis induces genomic instability in primary human fibroblast cells
title_short Particulate debris from a titanium metal prosthesis induces genomic instability in primary human fibroblast cells
title_sort particulate debris from a titanium metal prosthesis induces genomic instability in primary human fibroblast cells
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377169/
https://www.ncbi.nlm.nih.gov/pubmed/12592368
http://dx.doi.org/10.1038/sj.bjc.6600758
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