Cargando…

Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome

Quantifying the distribution of fitness effects among newly arising mutations in the human genome is key to resolving important debates in medical and evolutionary genetics. Here, we present a method for inferring this distribution using Single Nucleotide Polymorphism (SNP) data from a population wi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Boyko, Adam R., Williamson, Scott H., Indap, Amit R., Degenhardt, Jeremiah D., Hernandez, Ryan D., Lohmueller, Kirk E., Adams, Mark D., Schmidt, Steffen, Sninsky, John J., Sunyaev, Shamil R., White, Thomas J., Nielsen, Rasmus, Clark, Andrew G., Bustamante, Carlos D.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377339/ https://www.ncbi.nlm.nih.gov/pubmed/18516229 http://dx.doi.org/10.1371/journal.pgen.1000083

Ejemplares similares

Evolutionary Processes Acting on Candidate cis-Regulatory Regions in Humans Inferred from Patterns of Polymorphism and Divergence
por: Torgerson, Dara G., et al.
Publicado: (2009)

Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection
por: Lenz, Tobias L., et al.
Publicado: (2016)

A Model-Based Approach for Identifying Signatures of Ancient Balancing Selection in Genetic Data
por: DeGiorgio, Michael, et al.
Publicado: (2014)

Natural Selection Reduced Diversity on Human Y Chromosomes
por: Wilson Sayres, Melissa A., et al.
Publicado: (2014)

A Scan for Positively Selected Genes in the Genomes of Humans and Chimpanzees
por: Nielsen, Rasmus, et al.
Publicado: (2005)

Greater strength of selection and higher proportion of beneficial amino acid changing mutations in humans compared with mice and Drosophila melanogaster
por: Zhen, Ying, et al.
Publicado: (2021)

Biocomputing enters its adolescence
por: Sunyaev, Shamil
Publicado: (2005)

Maintenance of Complex Trait Variation: Classic Theory and Modern Data
por: Koch, Evan M., et al.
Publicado: (2021)

Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome
por: Garcia, Jesse A., et al.
Publicado: (2021)

Correction: Hypermutable Non-Synonymous Sites Are under Stronger Negative Selection
por: Schmidt, Steffen, et al.
Publicado: (2008)

Hypermutable Non-Synonymous Sites Are under Stronger Negative Selection
por: Schmidt, Steffen, et al.
Publicado: (2008)

A method and server for predicting damaging missense mutations
por: Adzhubei, Ivan A., et al.
Publicado: (2010)

Adaptive Mutations in the JC Virus Protein Capsid Are Associated with Progressive Multifocal Leukoencephalopathy (PML)
por: Sunyaev, Shamil R., et al.
Publicado: (2009)

Shared associations identify causal relationships between gene expression and immune cell phenotypes
por: Gasperi, Christiane, et al.
Publicado: (2021)

Localizing Recent Adaptive Evolution in the Human Genome
por: Williamson, Scott H, et al.
Publicado: (2007)

Computational and statistical approaches to analyzing variants identified by exome sequencing
por: Stitziel, Nathan O, et al.
Publicado: (2011)

StrVCTVRE: A supervised learning method to predict the pathogenicity of human genome structural variants
por: Sharo, Andrew G., et al.
Publicado: (2022)

Genome-Wide Patterns of Nucleotide Polymorphism in Domesticated Rice
por: Caicedo, Ana L, et al.
Publicado: (2007)

Analysis of Sequence Conservation at Nucleotide Resolution
por: Asthana, Saurabh, et al.
Publicado: (2007)

Determining the Effect of Natural Selection on Linked Neutral Divergence across Species
por: Phung, Tanya N., et al.
Publicado: (2016)

Deleterious variation shapes the genomic landscape of introgression
por: Kim, Bernard Y., et al.
Publicado: (2018)

Inference of the Distribution of Selection Coefficients for New Nonsynonymous Mutations Using Large Samples
por: Kim, Bernard Y., et al.
Publicado: (2017)

Population genetic models of GERP scores suggest pervasive turnover of constrained sites across mammalian evolution
por: Huber, Christian D., et al.
Publicado: (2020)

Metazoan Remaining Genes for Essential Amino Acid Biosynthesis: Sequence Conservation and Evolutionary Analyses
por: Costa, Igor R., et al.
Publicado: (2014)

The Impact of Population Demography and Selection on the Genetic Architecture of Complex Traits
por: Lohmueller, Kirk E.
Publicado: (2014)

A Simple Genetic Architecture Underlies Morphological Variation in Dogs
por: Boyko, Adam R., et al.
Publicado: (2010)

Dominance of Deleterious Alleles Controls the Response to a Population Bottleneck
por: Balick, Daniel J., et al.
Publicado: (2015)

Analysis of concordance of different haplotype block partitioning algorithms
por: Indap, Amit R, et al.
Publicado: (2005)

Variant discovery in targeted resequencing using whole genome amplified DNA
por: Indap, Amit R, et al.
Publicado: (2013)

Evolutionary Systems Biology of Amino Acid Biosynthetic Cost in Yeast
por: Barton, Michael D., et al.
Publicado: (2010)

Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective
por: Valerio, Alessandra, et al.
Publicado: (2011)

A literature review at genome scale: improving clinical variant assessment
por: Cassa, Christopher A., et al.
Publicado: (2018)

Recurrent mutation in the ancestry of a rare variant
por: Wakeley, John, et al.
Publicado: (2023)

Gene expression drives the evolution of dominance
por: Huber, Christian D., et al.
Publicado: (2018)

Replicate sequencing libraries are important for quantification of allelic imbalance
por: Mendelevich, Asia, et al.
Publicado: (2021)

Correction: Evolutionary Systems Biology of Amino Acid Biosynthetic Cost in Yeast
por: Barton, Michael D., et al.
Publicado: (2010)

No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans
por: Do, Ron, et al.
Publicado: (2015)

Inferring the mode and strength of ongoing selection
por: Barroso, Gustavo V., et al.
Publicado: (2023)

SCONCE2: jointly inferring single cell copy number profiles and tumor evolutionary distances
por: Hui, Sandra, et al.
Publicado: (2022)

PINES: phenotype-informed tissue weighting improves prediction of pathogenic noncoding variants
por: Bodea, Corneliu A., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_fru4j7es2p02eq3brjpan1nrjm