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Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome

Quantifying the distribution of fitness effects among newly arising mutations in the human genome is key to resolving important debates in medical and evolutionary genetics. Here, we present a method for inferring this distribution using Single Nucleotide Polymorphism (SNP) data from a population wi...

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Detalles Bibliográficos
Autores principales:	Boyko, Adam R., Williamson, Scott H., Indap, Amit R., Degenhardt, Jeremiah D., Hernandez, Ryan D., Lohmueller, Kirk E., Adams, Mark D., Schmidt, Steffen, Sninsky, John J., Sunyaev, Shamil R., White, Thomas J., Nielsen, Rasmus, Clark, Andrew G., Bustamante, Carlos D.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377339/ https://www.ncbi.nlm.nih.gov/pubmed/18516229 http://dx.doi.org/10.1371/journal.pgen.1000083

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