The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements

We have carried out a survey of potential quadruplex structure sequences (PQSS), which occur in the immediate upstream region (500 bp) of human genes. By examining the number and distribution of these we have established that there is a clear link between them and the occurrence of the SP1-binding e...

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Detalles Bibliográficos
Autores principales: Todd, Alan K., Neidle, Stephen
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377421/
https://www.ncbi.nlm.nih.gov/pubmed/18353860
http://dx.doi.org/10.1093/nar/gkn078
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author Todd, Alan K.
Neidle, Stephen
author_facet Todd, Alan K.
Neidle, Stephen
author_sort Todd, Alan K.
collection PubMed
description We have carried out a survey of potential quadruplex structure sequences (PQSS), which occur in the immediate upstream region (500 bp) of human genes. By examining the number and distribution of these we have established that there is a clear link between them and the occurrence of the SP1-binding element ‘GGGCGG’, such that a large number of upstream PQSS incorporate the SP1-binding element.
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spelling pubmed-23774212008-05-14 The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements Todd, Alan K. Neidle, Stephen Nucleic Acids Res Genomics We have carried out a survey of potential quadruplex structure sequences (PQSS), which occur in the immediate upstream region (500 bp) of human genes. By examining the number and distribution of these we have established that there is a clear link between them and the occurrence of the SP1-binding element ‘GGGCGG’, such that a large number of upstream PQSS incorporate the SP1-binding element. Oxford University Press 2008-05 2008-03-19 /pmc/articles/PMC2377421/ /pubmed/18353860 http://dx.doi.org/10.1093/nar/gkn078 Text en © 2008 The Author(s) http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Genomics
Todd, Alan K.
Neidle, Stephen
The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements
title The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements
title_full The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements
title_fullStr The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements
title_full_unstemmed The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements
title_short The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements
title_sort relationship of potential g-quadruplex sequences in cis-upstream regions of the human genome to sp1-binding elements
topic Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377421/
https://www.ncbi.nlm.nih.gov/pubmed/18353860
http://dx.doi.org/10.1093/nar/gkn078
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