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Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks

Non-homologous end-joining (NHEJ) of DNA double-strand breaks (DSBs) is mediated by two protein complexes comprising Ku80/Ku70/DNA-PKcs/Artemis and XRCC4/LigaseIV/XLF. Loss of Ku or XRCC4/LigaseIV function compromises the rejoining of radiation-induced DSBs and leads to defective V(D)J recombination...

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Detalles Bibliográficos
Autores principales:	Schulte-Uentrop, Leonie, El-Awady, Raafat A., Schliecker, Lena, Willers, Henning, Dahm-Daphi, Jochen
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377445/ https://www.ncbi.nlm.nih.gov/pubmed/18332040 http://dx.doi.org/10.1093/nar/gkn094

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