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Human abasic endonuclease action on multilesion abasic clusters: implications for radiation-induced biological damage
Clustered damages—two or more closely opposed abasic sites, oxidized bases or strand breaks—are induced in DNA by ionizing radiation and by some radiomimetic drugs. They are potentially mutagenic or lethal. High complexity, multilesion clusters (three or more lesions) are hypothesized as repair-resi...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377450/ https://www.ncbi.nlm.nih.gov/pubmed/18353858 http://dx.doi.org/10.1093/nar/gkn118 |