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Duplicated Paralogous Genes Subject to Positive Selection in the Genome of Trypanosoma brucei

BACKGROUND: Whole genome studies have highlighted duplicated genes as important substrates for adaptive evolution. We have investigated adaptive evolution in this class of genes in the human parasite Trypanosoma brucei, as indicated by the ratio of non-synonymous (amino-acid changing) to synonymous...

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Detalles Bibliográficos
Autores principales: Emes, Richard D., Yang, Ziheng
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386149/
https://www.ncbi.nlm.nih.gov/pubmed/18509460
http://dx.doi.org/10.1371/journal.pone.0002295
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author Emes, Richard D.
Yang, Ziheng
author_facet Emes, Richard D.
Yang, Ziheng
author_sort Emes, Richard D.
collection PubMed
description BACKGROUND: Whole genome studies have highlighted duplicated genes as important substrates for adaptive evolution. We have investigated adaptive evolution in this class of genes in the human parasite Trypanosoma brucei, as indicated by the ratio of non-synonymous (amino-acid changing) to synonymous (amino acid retaining) nucleotide substitution rates. METHODOLOGY/PRINCIPAL FINDINGS: We have identified duplicated genes that are most rapidly evolving in this important human parasite. This is the first attempt to investigate adaptive evolution in this species at the codon level. We identify 109 genes within 23 clusters of paralogous gene expansions to be subject to positive selection. CONCLUSIONS/SIGNIFICANCE: Genes identified include surface antigens in both the mammalian and insect host life cycle stage suggesting that competitive interaction is not solely with the adaptive immune system of the mammalian host. Also surface transporters related to drug resistance and genes related to developmental progression are detected. We discuss how adaptive evolution of these genes may highlight lineage specific processes essential for parasite survival. We also discuss the implications of adaptive evolution of these targets for parasite biology and control.
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spelling pubmed-23861492008-05-28 Duplicated Paralogous Genes Subject to Positive Selection in the Genome of Trypanosoma brucei Emes, Richard D. Yang, Ziheng PLoS One Research Article BACKGROUND: Whole genome studies have highlighted duplicated genes as important substrates for adaptive evolution. We have investigated adaptive evolution in this class of genes in the human parasite Trypanosoma brucei, as indicated by the ratio of non-synonymous (amino-acid changing) to synonymous (amino acid retaining) nucleotide substitution rates. METHODOLOGY/PRINCIPAL FINDINGS: We have identified duplicated genes that are most rapidly evolving in this important human parasite. This is the first attempt to investigate adaptive evolution in this species at the codon level. We identify 109 genes within 23 clusters of paralogous gene expansions to be subject to positive selection. CONCLUSIONS/SIGNIFICANCE: Genes identified include surface antigens in both the mammalian and insect host life cycle stage suggesting that competitive interaction is not solely with the adaptive immune system of the mammalian host. Also surface transporters related to drug resistance and genes related to developmental progression are detected. We discuss how adaptive evolution of these genes may highlight lineage specific processes essential for parasite survival. We also discuss the implications of adaptive evolution of these targets for parasite biology and control. Public Library of Science 2008-05-28 /pmc/articles/PMC2386149/ /pubmed/18509460 http://dx.doi.org/10.1371/journal.pone.0002295 Text en Emes, Yang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Emes, Richard D.
Yang, Ziheng
Duplicated Paralogous Genes Subject to Positive Selection in the Genome of Trypanosoma brucei
title Duplicated Paralogous Genes Subject to Positive Selection in the Genome of Trypanosoma brucei
title_full Duplicated Paralogous Genes Subject to Positive Selection in the Genome of Trypanosoma brucei
title_fullStr Duplicated Paralogous Genes Subject to Positive Selection in the Genome of Trypanosoma brucei
title_full_unstemmed Duplicated Paralogous Genes Subject to Positive Selection in the Genome of Trypanosoma brucei
title_short Duplicated Paralogous Genes Subject to Positive Selection in the Genome of Trypanosoma brucei
title_sort duplicated paralogous genes subject to positive selection in the genome of trypanosoma brucei
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386149/
https://www.ncbi.nlm.nih.gov/pubmed/18509460
http://dx.doi.org/10.1371/journal.pone.0002295
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