A Bacterial Cytotoxin Identifies the RhoA Exchange Factor Net1 as a Key Effector in the Response to DNA Damage

BACKGROUND: Exposure of adherent cells to DNA damaging agents, such as the bacterial cytolethal distending toxin (CDT) or ionizing radiations (IR), activates the small GTPase RhoA, which promotes the formation of actin stress fibers and delays cell death. The signalling intermediates that regulate R...

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Detalles Bibliográficos
Autores principales: Guerra, Lina, Carr, Heather S., Richter-Dahlfors, Agneta, Masucci, Maria G., Thelestam, Monica, Frost, Jeffrey A., Frisan, Teresa
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386254/
https://www.ncbi.nlm.nih.gov/pubmed/18509476
http://dx.doi.org/10.1371/journal.pone.0002254

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