Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta

BACKGROUND: Neuropeptide Y (NPY), agouti related peptide (AgRP), cocaine and amphetamine-regulated transcript (CART) and melanocortins, the products of the proopiomelanocortin (POMC), are hypothalamic peptides involved in feeding regulation and energy homeostasis. Recent evidence has demonstrated th...

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Autores principales: Caminos, Jorge E, Bravo, Susana B, González, C Ruth, Garcés, Maria F, Cepeda, Libia A, González, Adriana C, Cordido, Fernando, López, Miguel, Diéguez, Carlos
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386475/
https://www.ncbi.nlm.nih.gov/pubmed/18384674
http://dx.doi.org/10.1186/1477-7827-6-14
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author Caminos, Jorge E
Bravo, Susana B
González, C Ruth
Garcés, Maria F
Cepeda, Libia A
González, Adriana C
Cordido, Fernando
López, Miguel
Diéguez, Carlos
author_facet Caminos, Jorge E
Bravo, Susana B
González, C Ruth
Garcés, Maria F
Cepeda, Libia A
González, Adriana C
Cordido, Fernando
López, Miguel
Diéguez, Carlos
author_sort Caminos, Jorge E
collection PubMed
description BACKGROUND: Neuropeptide Y (NPY), agouti related peptide (AgRP), cocaine and amphetamine-regulated transcript (CART) and melanocortins, the products of the proopiomelanocortin (POMC), are hypothalamic peptides involved in feeding regulation and energy homeostasis. Recent evidence has demonstrated their expression in rat and human placenta. METHODS: In the current study, we have investigated the expression of those neuropeptides in the rat placenta by real-time PCR using a model of maternal food restriction. RESULTS: Our results showed that placental-derived neuropeptides were regulated through pregnancy and following food restriction. CONCLUSION: These data could indicate that placental-derived neuropeptides represent a local regulatory circuit that may fine-tune control of energy balance during pregnancy.
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spelling pubmed-23864752008-05-16 Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta Caminos, Jorge E Bravo, Susana B González, C Ruth Garcés, Maria F Cepeda, Libia A González, Adriana C Cordido, Fernando López, Miguel Diéguez, Carlos Reprod Biol Endocrinol Research BACKGROUND: Neuropeptide Y (NPY), agouti related peptide (AgRP), cocaine and amphetamine-regulated transcript (CART) and melanocortins, the products of the proopiomelanocortin (POMC), are hypothalamic peptides involved in feeding regulation and energy homeostasis. Recent evidence has demonstrated their expression in rat and human placenta. METHODS: In the current study, we have investigated the expression of those neuropeptides in the rat placenta by real-time PCR using a model of maternal food restriction. RESULTS: Our results showed that placental-derived neuropeptides were regulated through pregnancy and following food restriction. CONCLUSION: These data could indicate that placental-derived neuropeptides represent a local regulatory circuit that may fine-tune control of energy balance during pregnancy. BioMed Central 2008-04-02 /pmc/articles/PMC2386475/ /pubmed/18384674 http://dx.doi.org/10.1186/1477-7827-6-14 Text en Copyright © 2008 Caminos et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Caminos, Jorge E
Bravo, Susana B
González, C Ruth
Garcés, Maria F
Cepeda, Libia A
González, Adriana C
Cordido, Fernando
López, Miguel
Diéguez, Carlos
Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta
title Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta
title_full Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta
title_fullStr Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta
title_full_unstemmed Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta
title_short Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta
title_sort food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386475/
https://www.ncbi.nlm.nih.gov/pubmed/18384674
http://dx.doi.org/10.1186/1477-7827-6-14
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