Expression of HER-2 in MCF-7 breast cancer cells modulates anti-apoptotic proteins Survivin and Bcl-2 via the extracellular signal-related kinase (ERK) and phosphoinositide-3 kinase (PI3K) signalling pathways

BACKGROUND: The oncoprotein HER-2 is over-expressed and/or has undergone gene amplification in between 20 to 30% of breast and ovarian cancers. HER-2 amplified breast cancer is associated with a poor prognosis and increased resistance to chemo- and hormonal therapy. Data supporting the transforming...

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Detalles Bibliográficos
Autores principales: Siddiqa, Aisha, Long, Linda M, Li, Liuxia, Marciniak, Robert A, Kazhdan, Irene
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386479/
https://www.ncbi.nlm.nih.gov/pubmed/18454859
http://dx.doi.org/10.1186/1471-2407-8-129

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