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Distribution of transferrin binding protein B gene (tbpB) variants among Neisseria species
BACKGROUND: Transferrin binding protein B (tbpB), an outer membrane lipoprotein, is required for the acquisition of iron from human transferrin. Two tbpB families have been documented in Neisseria meningitidis: an isotype I tbpB gene of 1.8 kb and an isotype II tbpB gene of 2.1 kb, the former expres...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386816/ https://www.ncbi.nlm.nih.gov/pubmed/18430216 http://dx.doi.org/10.1186/1471-2180-8-66 |
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author | Harrison, Odile B Maiden, Martin CJ Rokbi, Bachra |
author_facet | Harrison, Odile B Maiden, Martin CJ Rokbi, Bachra |
author_sort | Harrison, Odile B |
collection | PubMed |
description | BACKGROUND: Transferrin binding protein B (tbpB), an outer membrane lipoprotein, is required for the acquisition of iron from human transferrin. Two tbpB families have been documented in Neisseria meningitidis: an isotype I tbpB gene of 1.8 kb and an isotype II tbpB gene of 2.1 kb, the former expressed by meningococci in the disease-associated ST-11 clonal complex and the latter found among meningococci belonging to the hyper-invasive clonal complexes including ST-8, ST-18, ST-32, ST-41/44 as well as N. gonorrhoeae isolates. The origin of the isotype I tbpB gene is unknown, however several features in common with non-pathogenic Neisseria and the ST-11 clonal complex N. meningitidis isolate FAM18 have been documented leading to the hypothesis that the isotype I tbpB gene may also be shared between non-pathogenic Neisseria and ST-11 meningococci. As a result, the diversity of the tbpB gene was investigated in a defined collection of Neisseria species. RESULTS: Two families of isotype I tbpB were identified: family A containing conserved genes belonging to ST-11 meningococci, N. polysaccharea and N. lactamica isolates and family B including more diverse isotype I tbpB genes from N. sicca, N. mucosa, N. flava, N. subflava as well as N. cinerea, N. flavescens and N. polysaccharea isolates. Three isotype II tbpB families were identified with: family C containing diverse tbpB genes belonging to N. polysaccharea, N. lactamica, N. gonorrhoeae and N. meningitidis isolates, family D including another subset of isotype II tbpB genes from N. lactamica isolates and family E solely composed of N. gonorrhoeae tbpB genes. CONCLUSION: This study reveals another instance of similarity between meningococci of the ST-11 clonal complex and non-pathogenic Neisseria with the origin of the isotype I tbpB gene resulting from a horizontal genetic transfer event occurring between these two populations. |
format | Text |
id | pubmed-2386816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-23868162008-05-17 Distribution of transferrin binding protein B gene (tbpB) variants among Neisseria species Harrison, Odile B Maiden, Martin CJ Rokbi, Bachra BMC Microbiol Research Article BACKGROUND: Transferrin binding protein B (tbpB), an outer membrane lipoprotein, is required for the acquisition of iron from human transferrin. Two tbpB families have been documented in Neisseria meningitidis: an isotype I tbpB gene of 1.8 kb and an isotype II tbpB gene of 2.1 kb, the former expressed by meningococci in the disease-associated ST-11 clonal complex and the latter found among meningococci belonging to the hyper-invasive clonal complexes including ST-8, ST-18, ST-32, ST-41/44 as well as N. gonorrhoeae isolates. The origin of the isotype I tbpB gene is unknown, however several features in common with non-pathogenic Neisseria and the ST-11 clonal complex N. meningitidis isolate FAM18 have been documented leading to the hypothesis that the isotype I tbpB gene may also be shared between non-pathogenic Neisseria and ST-11 meningococci. As a result, the diversity of the tbpB gene was investigated in a defined collection of Neisseria species. RESULTS: Two families of isotype I tbpB were identified: family A containing conserved genes belonging to ST-11 meningococci, N. polysaccharea and N. lactamica isolates and family B including more diverse isotype I tbpB genes from N. sicca, N. mucosa, N. flava, N. subflava as well as N. cinerea, N. flavescens and N. polysaccharea isolates. Three isotype II tbpB families were identified with: family C containing diverse tbpB genes belonging to N. polysaccharea, N. lactamica, N. gonorrhoeae and N. meningitidis isolates, family D including another subset of isotype II tbpB genes from N. lactamica isolates and family E solely composed of N. gonorrhoeae tbpB genes. CONCLUSION: This study reveals another instance of similarity between meningococci of the ST-11 clonal complex and non-pathogenic Neisseria with the origin of the isotype I tbpB gene resulting from a horizontal genetic transfer event occurring between these two populations. BioMed Central 2008-04-22 /pmc/articles/PMC2386816/ /pubmed/18430216 http://dx.doi.org/10.1186/1471-2180-8-66 Text en Copyright © 2008 Harrison et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Harrison, Odile B Maiden, Martin CJ Rokbi, Bachra Distribution of transferrin binding protein B gene (tbpB) variants among Neisseria species |
title | Distribution of transferrin binding protein B gene (tbpB) variants among Neisseria species |
title_full | Distribution of transferrin binding protein B gene (tbpB) variants among Neisseria species |
title_fullStr | Distribution of transferrin binding protein B gene (tbpB) variants among Neisseria species |
title_full_unstemmed | Distribution of transferrin binding protein B gene (tbpB) variants among Neisseria species |
title_short | Distribution of transferrin binding protein B gene (tbpB) variants among Neisseria species |
title_sort | distribution of transferrin binding protein b gene (tbpb) variants among neisseria species |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386816/ https://www.ncbi.nlm.nih.gov/pubmed/18430216 http://dx.doi.org/10.1186/1471-2180-8-66 |
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