A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle

BACKGROUND: Marbling score (MS) is the major quantitative trait that affects carcass quality in beef cattle. In this study, we examined the association between genetic polymorphisms of the micromolar calcium-activated neutral protease gene (micro-calpain, CAPN1) and carcass traits in Korean cattle (...

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Autores principales: Cheong, Hyun Sub, Yoon, Du-Hak, Park, Byung Lae, Kim, Lyoung Hyo, Bae, Joon Seol, Namgoong, Sohg, Lee, Hae Won, Han, Chang Soo, Kim, Ji On, Cheong, Il-Cheong, Shin, Hyoung Doo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
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Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386817/
https://www.ncbi.nlm.nih.gov/pubmed/18423040
http://dx.doi.org/10.1186/1471-2156-9-33
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author Cheong, Hyun Sub
Yoon, Du-Hak
Park, Byung Lae
Kim, Lyoung Hyo
Bae, Joon Seol
Namgoong, Sohg
Lee, Hae Won
Han, Chang Soo
Kim, Ji On
Cheong, Il-Cheong
Shin, Hyoung Doo
author_facet Cheong, Hyun Sub
Yoon, Du-Hak
Park, Byung Lae
Kim, Lyoung Hyo
Bae, Joon Seol
Namgoong, Sohg
Lee, Hae Won
Han, Chang Soo
Kim, Ji On
Cheong, Il-Cheong
Shin, Hyoung Doo
author_sort Cheong, Hyun Sub
collection PubMed
description BACKGROUND: Marbling score (MS) is the major quantitative trait that affects carcass quality in beef cattle. In this study, we examined the association between genetic polymorphisms of the micromolar calcium-activated neutral protease gene (micro-calpain, CAPN1) and carcass traits in Korean cattle (also known as Hanwoo). RESULTS: By direct DNA sequencing in 24 unrelated Korean cattle, we identified 39 sequence variants within exons and their flanking regions in CAPN1. Among them, 12 common polymorphic sites were selected for genotyping in the beef cattle (n = 421). Statistical analysis revealed that a polymorphism in the 3'UTR (c.2151*479C>T) showed significant association with MS (P(cor. )= 0.02). CONCLUSION: Our findings suggest that polymorphisms in CAPN1 might be one of the important genetic factors involved in carcass quality in beef cattle, although it could be false positive association.
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spelling pubmed-23868172008-05-17 A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle Cheong, Hyun Sub Yoon, Du-Hak Park, Byung Lae Kim, Lyoung Hyo Bae, Joon Seol Namgoong, Sohg Lee, Hae Won Han, Chang Soo Kim, Ji On Cheong, Il-Cheong Shin, Hyoung Doo BMC Genet Research Article BACKGROUND: Marbling score (MS) is the major quantitative trait that affects carcass quality in beef cattle. In this study, we examined the association between genetic polymorphisms of the micromolar calcium-activated neutral protease gene (micro-calpain, CAPN1) and carcass traits in Korean cattle (also known as Hanwoo). RESULTS: By direct DNA sequencing in 24 unrelated Korean cattle, we identified 39 sequence variants within exons and their flanking regions in CAPN1. Among them, 12 common polymorphic sites were selected for genotyping in the beef cattle (n = 421). Statistical analysis revealed that a polymorphism in the 3'UTR (c.2151*479C>T) showed significant association with MS (P(cor. )= 0.02). CONCLUSION: Our findings suggest that polymorphisms in CAPN1 might be one of the important genetic factors involved in carcass quality in beef cattle, although it could be false positive association. BioMed Central 2008-04-19 /pmc/articles/PMC2386817/ /pubmed/18423040 http://dx.doi.org/10.1186/1471-2156-9-33 Text en Copyright © 2008 Cheong et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cheong, Hyun Sub
Yoon, Du-Hak
Park, Byung Lae
Kim, Lyoung Hyo
Bae, Joon Seol
Namgoong, Sohg
Lee, Hae Won
Han, Chang Soo
Kim, Ji On
Cheong, Il-Cheong
Shin, Hyoung Doo
A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle
title A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle
title_full A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle
title_fullStr A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle
title_full_unstemmed A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle
title_short A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle
title_sort single nucleotide polymorphism in capn1 associated with marbling score in korean cattle
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386817/
https://www.ncbi.nlm.nih.gov/pubmed/18423040
http://dx.doi.org/10.1186/1471-2156-9-33
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