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Human Islet Amyloid Polypeptide Transgenic Mice: In Vivo and Ex Vivo Models for the Role of hIAPP in Type 2 Diabetes Mellitus

Human islet amyloid polypeptide (hIAPP), a pancreatic islet protein of 37 amino acids, is the main component of islet amyloid, seen at autopsy in patients with type 2 diabetes mellitus (DM2). To investigate the roles of hIAPP and islet amyloid in DM2, we generated transgenic mice expressing hIAPP in...

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Detalles Bibliográficos
Autores principales:	Höppener, J. W. M., Jacobs, H. M., Wierup, N., Sotthewes, G., Sprong, M., de Vos, P., Berger, R., Sundler, F., Ahrén, B.
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386890/ https://www.ncbi.nlm.nih.gov/pubmed/18497871 http://dx.doi.org/10.1155/2008/697035

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