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DNA demethylation-dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves SP1-activated transcription

BACKGROUND: The clinical course of cystic fibrosis (CF) is characterized by recurrent pulmonary infections and chronic inflammation. We have recently shown that decreased methylation of the toll-like receptor-2 (TLR2) promoter leads to an apparent CF-related up-regulation of TLR2. This up-regulation...

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Detalles Bibliográficos
Autores principales:	Furuta, Takashi, Shuto, Tsuyoshi, Shimasaki, Shogo, Ohira, Yuko, Suico, Mary Ann, Gruenert, Dieter C, Kai, Hirofumi
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2387165/ https://www.ncbi.nlm.nih.gov/pubmed/18423053 http://dx.doi.org/10.1186/1471-2199-9-39

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