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Pentamidine Dosage: A Base/Salt Confusion
Pentamidine has a long history in the treatment of human African trypanosomiasis (HAT) and leishmaniasis. Early guidelines on the dosage of pentamidine were based on the base-moiety of the two different formulations available. Confusion on the dosage of pentamidine arose from a different labelling o...
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2387188/ https://www.ncbi.nlm.nih.gov/pubmed/18509543 http://dx.doi.org/10.1371/journal.pntd.0000225 |
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author | Dorlo, Thomas P. C. Kager, Piet A. |
author_facet | Dorlo, Thomas P. C. Kager, Piet A. |
author_sort | Dorlo, Thomas P. C. |
collection | PubMed |
description | Pentamidine has a long history in the treatment of human African trypanosomiasis (HAT) and leishmaniasis. Early guidelines on the dosage of pentamidine were based on the base-moiety of the two different formulations available. Confusion on the dosage of pentamidine arose from a different labelling of the two available products, either based on the salt or base moiety available in the preparation. We provide an overview of the various guidelines concerning HAT and leishmaniasis over the past decades and show the confusion in the calculation of the dosage of pentamidine in these guidelines and the subsequent published reports on clinical trials and reviews. At present, only pentamidine isethionate is available, but the advised dosage for HAT and leishmaniasis is (historically) based on the amount of pentamidine base. In the treatment of leishmaniasis this is probably resulting in a subtherapeutic treatment. There is thus a need for a new, more transparent and concise guideline concerning the dosage of pentamidine, at least in the treatment of HAT and leishmaniasis. |
format | Text |
id | pubmed-2387188 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-23871882008-05-28 Pentamidine Dosage: A Base/Salt Confusion Dorlo, Thomas P. C. Kager, Piet A. PLoS Negl Trop Dis Policy Platform Pentamidine has a long history in the treatment of human African trypanosomiasis (HAT) and leishmaniasis. Early guidelines on the dosage of pentamidine were based on the base-moiety of the two different formulations available. Confusion on the dosage of pentamidine arose from a different labelling of the two available products, either based on the salt or base moiety available in the preparation. We provide an overview of the various guidelines concerning HAT and leishmaniasis over the past decades and show the confusion in the calculation of the dosage of pentamidine in these guidelines and the subsequent published reports on clinical trials and reviews. At present, only pentamidine isethionate is available, but the advised dosage for HAT and leishmaniasis is (historically) based on the amount of pentamidine base. In the treatment of leishmaniasis this is probably resulting in a subtherapeutic treatment. There is thus a need for a new, more transparent and concise guideline concerning the dosage of pentamidine, at least in the treatment of HAT and leishmaniasis. Public Library of Science 2008-05-28 /pmc/articles/PMC2387188/ /pubmed/18509543 http://dx.doi.org/10.1371/journal.pntd.0000225 Text en Dorlo, Kager. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Policy Platform Dorlo, Thomas P. C. Kager, Piet A. Pentamidine Dosage: A Base/Salt Confusion |
title | Pentamidine Dosage: A Base/Salt Confusion |
title_full | Pentamidine Dosage: A Base/Salt Confusion |
title_fullStr | Pentamidine Dosage: A Base/Salt Confusion |
title_full_unstemmed | Pentamidine Dosage: A Base/Salt Confusion |
title_short | Pentamidine Dosage: A Base/Salt Confusion |
title_sort | pentamidine dosage: a base/salt confusion |
topic | Policy Platform |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2387188/ https://www.ncbi.nlm.nih.gov/pubmed/18509543 http://dx.doi.org/10.1371/journal.pntd.0000225 |
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