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Astrocytes Optimize the Synaptic Transmission of Information
Chemical synapses transmit information via the release of neurotransmitter-filled vesicles from the presynaptic terminal. Using computational modeling, we predict that the limited availability of neurotransmitter resources in combination with the spontaneous release of vesicles limits the maximum de...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2390854/ https://www.ncbi.nlm.nih.gov/pubmed/18516277 http://dx.doi.org/10.1371/journal.pcbi.1000088 |
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author | Nadkarni, Suhita Jung, Peter Levine, Herbert |
author_facet | Nadkarni, Suhita Jung, Peter Levine, Herbert |
author_sort | Nadkarni, Suhita |
collection | PubMed |
description | Chemical synapses transmit information via the release of neurotransmitter-filled vesicles from the presynaptic terminal. Using computational modeling, we predict that the limited availability of neurotransmitter resources in combination with the spontaneous release of vesicles limits the maximum degree of enhancement of synaptic transmission. This gives rise to an optimal tuning that depends on the number of active zones. There is strong experimental evidence that astrocytes that enwrap synapses can modulate the probabilities of vesicle release through bidirectional signaling and hence regulate synaptic transmission. For low-fidelity hippocampal synapses, which typically have only one or two active zones, the predicted optimal values lie close to those determined by experimentally measured astrocytic feedback, suggesting that astrocytes optimize synaptic transmission of information. |
format | Text |
id | pubmed-2390854 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-23908542008-05-30 Astrocytes Optimize the Synaptic Transmission of Information Nadkarni, Suhita Jung, Peter Levine, Herbert PLoS Comput Biol Research Article Chemical synapses transmit information via the release of neurotransmitter-filled vesicles from the presynaptic terminal. Using computational modeling, we predict that the limited availability of neurotransmitter resources in combination with the spontaneous release of vesicles limits the maximum degree of enhancement of synaptic transmission. This gives rise to an optimal tuning that depends on the number of active zones. There is strong experimental evidence that astrocytes that enwrap synapses can modulate the probabilities of vesicle release through bidirectional signaling and hence regulate synaptic transmission. For low-fidelity hippocampal synapses, which typically have only one or two active zones, the predicted optimal values lie close to those determined by experimentally measured astrocytic feedback, suggesting that astrocytes optimize synaptic transmission of information. Public Library of Science 2008-05-30 /pmc/articles/PMC2390854/ /pubmed/18516277 http://dx.doi.org/10.1371/journal.pcbi.1000088 Text en Nadkarni et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Nadkarni, Suhita Jung, Peter Levine, Herbert Astrocytes Optimize the Synaptic Transmission of Information |
title | Astrocytes Optimize the Synaptic Transmission of Information |
title_full | Astrocytes Optimize the Synaptic Transmission of Information |
title_fullStr | Astrocytes Optimize the Synaptic Transmission of Information |
title_full_unstemmed | Astrocytes Optimize the Synaptic Transmission of Information |
title_short | Astrocytes Optimize the Synaptic Transmission of Information |
title_sort | astrocytes optimize the synaptic transmission of information |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2390854/ https://www.ncbi.nlm.nih.gov/pubmed/18516277 http://dx.doi.org/10.1371/journal.pcbi.1000088 |
work_keys_str_mv | AT nadkarnisuhita astrocytesoptimizethesynaptictransmissionofinformation AT jungpeter astrocytesoptimizethesynaptictransmissionofinformation AT levineherbert astrocytesoptimizethesynaptictransmissionofinformation |