EML4–ALK fusion transcript is not found in gastrointestinal and breast cancers

Fusion genes have been identified as chromosomal rearrangements in certain cancers, such as leukaemia, lymphoma, and sarcoma. The EML4–ALK (EML4: echinoderm microtubule-associated-protein-like 4; ALK: anaplastic lymphoma kinase) fusion gene has been identified as an oncogene in non-small-cell lung c...

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Autores principales: Fukuyoshi, Y, Inoue, H, Kita, Y, Utsunomiya, T, Ishida, T, Mori, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2391097/
https://www.ncbi.nlm.nih.gov/pubmed/18414414
http://dx.doi.org/10.1038/sj.bjc.6604341
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author Fukuyoshi, Y
Inoue, H
Kita, Y
Utsunomiya, T
Ishida, T
Mori, M
author_facet Fukuyoshi, Y
Inoue, H
Kita, Y
Utsunomiya, T
Ishida, T
Mori, M
author_sort Fukuyoshi, Y
collection PubMed
description Fusion genes have been identified as chromosomal rearrangements in certain cancers, such as leukaemia, lymphoma, and sarcoma. The EML4–ALK (EML4: echinoderm microtubule-associated-protein-like 4; ALK: anaplastic lymphoma kinase) fusion gene has been identified as an oncogene in non-small-cell lung cancer (NSCLC). This study examined the presence of this fusion transcript in gastrointestinal and breast cancers. We evaluated the expression of the EML4–ALK transcript in 104 lung cancer cases and in 645 gastrointestinal and breast cancer samples. Only one of the lung cancer samples tested positive for the EML4–ALK fusion transcript, whereas none were detected in 555 gastrointestinal and 90 breast cancer cases. Our data suggest that the EML4–ALK fusion transcript is not present in gastrointestinal or breast cancers and is specific to NSCLC.
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spelling pubmed-23910972009-09-10 EML4–ALK fusion transcript is not found in gastrointestinal and breast cancers Fukuyoshi, Y Inoue, H Kita, Y Utsunomiya, T Ishida, T Mori, M Br J Cancer Molecular Diagnostics Fusion genes have been identified as chromosomal rearrangements in certain cancers, such as leukaemia, lymphoma, and sarcoma. The EML4–ALK (EML4: echinoderm microtubule-associated-protein-like 4; ALK: anaplastic lymphoma kinase) fusion gene has been identified as an oncogene in non-small-cell lung cancer (NSCLC). This study examined the presence of this fusion transcript in gastrointestinal and breast cancers. We evaluated the expression of the EML4–ALK transcript in 104 lung cancer cases and in 645 gastrointestinal and breast cancer samples. Only one of the lung cancer samples tested positive for the EML4–ALK fusion transcript, whereas none were detected in 555 gastrointestinal and 90 breast cancer cases. Our data suggest that the EML4–ALK fusion transcript is not present in gastrointestinal or breast cancers and is specific to NSCLC. Nature Publishing Group 2008-05-06 2008-04-15 /pmc/articles/PMC2391097/ /pubmed/18414414 http://dx.doi.org/10.1038/sj.bjc.6604341 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular Diagnostics
Fukuyoshi, Y
Inoue, H
Kita, Y
Utsunomiya, T
Ishida, T
Mori, M
EML4–ALK fusion transcript is not found in gastrointestinal and breast cancers
title EML4–ALK fusion transcript is not found in gastrointestinal and breast cancers
title_full EML4–ALK fusion transcript is not found in gastrointestinal and breast cancers
title_fullStr EML4–ALK fusion transcript is not found in gastrointestinal and breast cancers
title_full_unstemmed EML4–ALK fusion transcript is not found in gastrointestinal and breast cancers
title_short EML4–ALK fusion transcript is not found in gastrointestinal and breast cancers
title_sort eml4–alk fusion transcript is not found in gastrointestinal and breast cancers
topic Molecular Diagnostics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2391097/
https://www.ncbi.nlm.nih.gov/pubmed/18414414
http://dx.doi.org/10.1038/sj.bjc.6604341
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