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Cigarette smoke induces genetic instability in airway epithelial cells by suppressing FANCD2 expression

Chromosomal abnormalities are commonly found in bronchogenic carcinoma cells, but the molecular causes of chromosomal instability (CIN) and their relationship to cigarette smoke has not been defined. Because the Fanconi anaemia (FA)/BRCA pathway is essential for maintenance of chromosomal stability,...

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Detalles Bibliográficos
Autores principales:	Hays, L E, Zodrow, D M, Yates, J E, Deffebach, M E, Jacoby, D B, Olson, S B, Pankow, J F, Bagby, G C
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2008
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2391131/ https://www.ncbi.nlm.nih.gov/pubmed/18475298 http://dx.doi.org/10.1038/sj.bjc.6604362

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