Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis

Particular types of human papillomavirus (HPV) infection may preferentially progress from high-grade squamous intraepithelial lesions (HSIL) to squamous cell carcinoma of the cervix (SCC). We performed a meta-analysis of published data to compare HPV type distribution in HSIL and SCC. HPV16, 18 and...

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Autores principales: Clifford, G M, Smith, J S, Aguado, T, Franceschi, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394204/
https://www.ncbi.nlm.nih.gov/pubmed/12838308
http://dx.doi.org/10.1038/sj.bjc.6601024
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author Clifford, G M
Smith, J S
Aguado, T
Franceschi, S
author_facet Clifford, G M
Smith, J S
Aguado, T
Franceschi, S
author_sort Clifford, G M
collection PubMed
description Particular types of human papillomavirus (HPV) infection may preferentially progress from high-grade squamous intraepithelial lesions (HSIL) to squamous cell carcinoma of the cervix (SCC). We performed a meta-analysis of published data to compare HPV type distribution in HSIL and SCC. HPV16, 18 and 45 were each more prevalent in SCC than HSIL, whereas the reverse was true for other oncogenic types including HPV31, 33, 52 and 58. These data suggest that HSILs infected with HPV16, 18 and 45 preferentially progress to SCC. This may have implications for follow-up protocols of future HPV-based cervical cancer screening programmes and for HPV vaccine trials.
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spelling pubmed-23942042009-09-10 Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis Clifford, G M Smith, J S Aguado, T Franceschi, S Br J Cancer Molecular and Cellular Pathology Particular types of human papillomavirus (HPV) infection may preferentially progress from high-grade squamous intraepithelial lesions (HSIL) to squamous cell carcinoma of the cervix (SCC). We performed a meta-analysis of published data to compare HPV type distribution in HSIL and SCC. HPV16, 18 and 45 were each more prevalent in SCC than HSIL, whereas the reverse was true for other oncogenic types including HPV31, 33, 52 and 58. These data suggest that HSILs infected with HPV16, 18 and 45 preferentially progress to SCC. This may have implications for follow-up protocols of future HPV-based cervical cancer screening programmes and for HPV vaccine trials. Nature Publishing Group 2003-07-07 2003-07-01 /pmc/articles/PMC2394204/ /pubmed/12838308 http://dx.doi.org/10.1038/sj.bjc.6601024 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Clifford, G M
Smith, J S
Aguado, T
Franceschi, S
Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis
title Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis
title_full Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis
title_fullStr Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis
title_full_unstemmed Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis
title_short Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis
title_sort comparison of hpv type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394204/
https://www.ncbi.nlm.nih.gov/pubmed/12838308
http://dx.doi.org/10.1038/sj.bjc.6601024
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