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Roles of the PI-3K and MEK pathways in Ras-mediated chemoresistance in breast cancer cells

Activated Ras utilises several downstream pathways, including the mitogen-activated protein kinase (MAPK) kinase (MEK)/MAPK pathway and the phosphoinositide 3-kinase (PI-3k)/Akt pathway, to promote cell proliferation and to inhibit apoptosis. To investigate which pathway plays a major role in Ras-in...

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Detalles Bibliográficos
Autores principales:	Jin, W, Wu, L, Liang, K, Liu, B, Lu, Y, Fan, Z
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2003
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394213/ https://www.ncbi.nlm.nih.gov/pubmed/12838322 http://dx.doi.org/10.1038/sj.bjc.6601048

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