New molecular pathways in angiogenesis

Angiogenesis has developed into a major area of cancer research. Recently, several newly identified signalling pathways have been shown to play a role in both normal and pathological (including tumour) angiogenesis. Several of the molecules involved in these pathways have potential as novel anti-can...

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Detalles Bibliográficos
Autores principales: Sullivan, D C, Bicknell, R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394258/
https://www.ncbi.nlm.nih.gov/pubmed/12865906
http://dx.doi.org/10.1038/sj.bjc.6601107
Descripción
Sumario:Angiogenesis has developed into a major area of cancer research. Recently, several newly identified signalling pathways have been shown to play a role in both normal and pathological (including tumour) angiogenesis. Several of the molecules involved in these pathways have potential as novel anti-cancer therapeutic targets including members of the ephrin/Eph receptor, Notch/delta, sprouty, hedgehog and roundabout/slit families. These developments are reviewed.

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