Vascular endothelial growth factor in node-positive breast cancer patients treated with adjuvant tamoxifen

In 212 postmenopausal women with node-positive oestrogen receptor-positive (ER(LBA)) breast cancer subjected to radical surgery and adjuvant tamoxifen, the risk of 6-year relapse increased with increasing values of intratumoral vascular endothelial growth factor (VEGF) in patients whose tumours had...

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Autores principales: Coradini, D, Biganzoli, E, Pellizzaro, C, Veneroni, S, Oriana, S, Ambrogi, F, Erdas, R, Boracchi, P, Daidone, M G, Marubini, E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394273/
https://www.ncbi.nlm.nih.gov/pubmed/12865915
http://dx.doi.org/10.1038/sj.bjc.6601060
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author Coradini, D
Biganzoli, E
Pellizzaro, C
Veneroni, S
Oriana, S
Ambrogi, F
Erdas, R
Boracchi, P
Daidone, M G
Marubini, E
author_facet Coradini, D
Biganzoli, E
Pellizzaro, C
Veneroni, S
Oriana, S
Ambrogi, F
Erdas, R
Boracchi, P
Daidone, M G
Marubini, E
author_sort Coradini, D
collection PubMed
description In 212 postmenopausal women with node-positive oestrogen receptor-positive (ER(LBA)) breast cancer subjected to radical surgery and adjuvant tamoxifen, the risk of 6-year relapse increased with increasing values of intratumoral vascular endothelial growth factor (VEGF) in patients whose tumours had a low/intermediate ER(LBA) content compared to patients with high-ER(LBA) tumours. These findings indicate that tumour progression, activated or sustained by high VEGF levels, may be counteracted in high-ER(LBA) cancers by tamoxifen, which in contrast fails to contrast the metastatic potential in low-ER(LBA) tumours.
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spelling pubmed-23942732009-09-10 Vascular endothelial growth factor in node-positive breast cancer patients treated with adjuvant tamoxifen Coradini, D Biganzoli, E Pellizzaro, C Veneroni, S Oriana, S Ambrogi, F Erdas, R Boracchi, P Daidone, M G Marubini, E Br J Cancer Molecular and Cellular Pathology In 212 postmenopausal women with node-positive oestrogen receptor-positive (ER(LBA)) breast cancer subjected to radical surgery and adjuvant tamoxifen, the risk of 6-year relapse increased with increasing values of intratumoral vascular endothelial growth factor (VEGF) in patients whose tumours had a low/intermediate ER(LBA) content compared to patients with high-ER(LBA) tumours. These findings indicate that tumour progression, activated or sustained by high VEGF levels, may be counteracted in high-ER(LBA) cancers by tamoxifen, which in contrast fails to contrast the metastatic potential in low-ER(LBA) tumours. Nature Publishing Group 2003-07-21 2003-07-15 /pmc/articles/PMC2394273/ /pubmed/12865915 http://dx.doi.org/10.1038/sj.bjc.6601060 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Coradini, D
Biganzoli, E
Pellizzaro, C
Veneroni, S
Oriana, S
Ambrogi, F
Erdas, R
Boracchi, P
Daidone, M G
Marubini, E
Vascular endothelial growth factor in node-positive breast cancer patients treated with adjuvant tamoxifen
title Vascular endothelial growth factor in node-positive breast cancer patients treated with adjuvant tamoxifen
title_full Vascular endothelial growth factor in node-positive breast cancer patients treated with adjuvant tamoxifen
title_fullStr Vascular endothelial growth factor in node-positive breast cancer patients treated with adjuvant tamoxifen
title_full_unstemmed Vascular endothelial growth factor in node-positive breast cancer patients treated with adjuvant tamoxifen
title_short Vascular endothelial growth factor in node-positive breast cancer patients treated with adjuvant tamoxifen
title_sort vascular endothelial growth factor in node-positive breast cancer patients treated with adjuvant tamoxifen
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394273/
https://www.ncbi.nlm.nih.gov/pubmed/12865915
http://dx.doi.org/10.1038/sj.bjc.6601060
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