Increased NF-κB DNA binding but not transcriptional activity during apoptosis induced by the COX-2-selective inhibitor NS-398 in colorectal carcinoma cells

Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit colorectal neoplasia, an effect that is associated with their ability to induce apoptosis. Although NSAIDs have been reported to inhibit NF-κB, more recent studies show activation of NF-κB by NSAIDs. NF-κB commonly shows antiapoptotic activity an...

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Detalles Bibliográficos
Autores principales: Smartt, H J M, Elder, D J E, Hicks, D J, Williams, N A, Paraskeva, C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394298/
https://www.ncbi.nlm.nih.gov/pubmed/14520472
http://dx.doi.org/10.1038/sj.bjc.6601266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394298/
https://www.ncbi.nlm.nih.gov/pubmed/14520472
http://dx.doi.org/10.1038/sj.bjc.6601266

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