Membranous location of EGFR immunostaining is associated with good prognosis in renal cell carcinoma

Epidermal growth factor receptor (EGFR) is a key factor in tumorigenesis. The association between EGFR expression and prognosis in renal cell carcinoma (RCC) is not clear. In our study of 134 RCCs, the cellular location of immunostaining was evaluated and patients with EGFR-positive tumours with pro...

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Autores principales: Kallio, J P, Hirvikoski, P, Helin, H, Kellokumpu-Lehtinen, P, Luukkaala, T, Tammela, T L J, Martikainen, P M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394310/
https://www.ncbi.nlm.nih.gov/pubmed/14520458
http://dx.doi.org/10.1038/sj.bjc.6601241
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author Kallio, J P
Hirvikoski, P
Helin, H
Kellokumpu-Lehtinen, P
Luukkaala, T
Tammela, T L J
Martikainen, P M
author_facet Kallio, J P
Hirvikoski, P
Helin, H
Kellokumpu-Lehtinen, P
Luukkaala, T
Tammela, T L J
Martikainen, P M
author_sort Kallio, J P
collection PubMed
description Epidermal growth factor receptor (EGFR) is a key factor in tumorigenesis. The association between EGFR expression and prognosis in renal cell carcinoma (RCC) is not clear. In our study of 134 RCCs, the cellular location of immunostaining was evaluated and patients with EGFR-positive tumours with prominent membranous staining had a good prognosis. Their overall survival was significantly longer (P=0.004) than that of patients with either EGFR-negative tumours or with mainly cytoplasmic staining. However, further studies on the different EGFR expression patterns in RCC are needed to clarify their role in the progression of the disease.
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spelling pubmed-23943102009-09-10 Membranous location of EGFR immunostaining is associated with good prognosis in renal cell carcinoma Kallio, J P Hirvikoski, P Helin, H Kellokumpu-Lehtinen, P Luukkaala, T Tammela, T L J Martikainen, P M Br J Cancer Molecular and Cellular Pathology Epidermal growth factor receptor (EGFR) is a key factor in tumorigenesis. The association between EGFR expression and prognosis in renal cell carcinoma (RCC) is not clear. In our study of 134 RCCs, the cellular location of immunostaining was evaluated and patients with EGFR-positive tumours with prominent membranous staining had a good prognosis. Their overall survival was significantly longer (P=0.004) than that of patients with either EGFR-negative tumours or with mainly cytoplasmic staining. However, further studies on the different EGFR expression patterns in RCC are needed to clarify their role in the progression of the disease. Nature Publishing Group 2003-10-06 2003-09-30 /pmc/articles/PMC2394310/ /pubmed/14520458 http://dx.doi.org/10.1038/sj.bjc.6601241 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Kallio, J P
Hirvikoski, P
Helin, H
Kellokumpu-Lehtinen, P
Luukkaala, T
Tammela, T L J
Martikainen, P M
Membranous location of EGFR immunostaining is associated with good prognosis in renal cell carcinoma
title Membranous location of EGFR immunostaining is associated with good prognosis in renal cell carcinoma
title_full Membranous location of EGFR immunostaining is associated with good prognosis in renal cell carcinoma
title_fullStr Membranous location of EGFR immunostaining is associated with good prognosis in renal cell carcinoma
title_full_unstemmed Membranous location of EGFR immunostaining is associated with good prognosis in renal cell carcinoma
title_short Membranous location of EGFR immunostaining is associated with good prognosis in renal cell carcinoma
title_sort membranous location of egfr immunostaining is associated with good prognosis in renal cell carcinoma
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394310/
https://www.ncbi.nlm.nih.gov/pubmed/14520458
http://dx.doi.org/10.1038/sj.bjc.6601241
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