Modified de Gramont with oxaliplatin in the first-line treatment of advanced colorectal cancer

We previously reported high activity for oxaliplatin and a modified de Gramont regimen (OxMdG) in a single centre study of patients with metastatic colorectal cancer. We now report results with a further 56 patients treated at 14 centres. Low rates of grade 3 and 4 toxicity were seen, with no toxic...

Descripción completa

Detalles Bibliográficos
Autores principales: Braun, M S, Adab, F, Bradley, C, McAdam, K, Thomas, G, Wadd, N J, Rea, D, Philips, R, Twelves, C, Bozzino, J, MacMillan, C, Saunders, M P, Counsell, R, Anderson, H, McDonald, A, Stewart, J, Robinson, A, Davies, S, Richards, F J, Seymour, M T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394314/
https://www.ncbi.nlm.nih.gov/pubmed/14520437
http://dx.doi.org/10.1038/sj.bjc.6601237
Descripción
Sumario:We previously reported high activity for oxaliplatin and a modified de Gramont regimen (OxMdG) in a single centre study of patients with metastatic colorectal cancer. We now report results with a further 56 patients treated at 14 centres. Low rates of grade 3 and 4 toxicity were seen, with no toxic deaths. Objective response rates were CR/PR=53%; NC=34.7%; PD=12.2%. Median time to progression was 8.3 months and overall survival was 14.5 months. This regimen is more convenient than those based around the conventional de Gramont regimen but is highly active and well tolerated; it forms part of a current UK MRC phase 3 trial.

Ejemplares similares