CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation

Vaccination with autologous leukaemia-derived dendritic cells (DC) presents an adjuvant treatment option for chronic myeloid leukaemia (CML). Here, we show that high-efficiency CD40-targeted adenoviral gene transfer of GM-CSF to CML-derived DC induces long-lived maturation in the absence of exogenou...

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Detalles Bibliográficos
Autores principales: Stam, A G M, Santegoets, S J A M, Westers, T M, Sombroek, C C, Janssen, J J W M, Tillman, B W, Loosdrecht, A A van de, Pinedo, H M, Curiel, D T, Ossenkoppele, G J, Scheper, R J, de Gruijl, T D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394320/
https://www.ncbi.nlm.nih.gov/pubmed/14520439
http://dx.doi.org/10.1038/sj.bjc.6601225
Descripción
Sumario:Vaccination with autologous leukaemia-derived dendritic cells (DC) presents an adjuvant treatment option for chronic myeloid leukaemia (CML). Here, we show that high-efficiency CD40-targeted adenoviral gene transfer of GM-CSF to CML-derived DC induces long-lived maturation in the absence of exogenous cytokines and may thus ensure protracted stimulation of CML-specific T cells upon vaccination.

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