CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation

Vaccination with autologous leukaemia-derived dendritic cells (DC) presents an adjuvant treatment option for chronic myeloid leukaemia (CML). Here, we show that high-efficiency CD40-targeted adenoviral gene transfer of GM-CSF to CML-derived DC induces long-lived maturation in the absence of exogenou...

Descripción completa

Detalles Bibliográficos
Autores principales: Stam, A G M, Santegoets, S J A M, Westers, T M, Sombroek, C C, Janssen, J J W M, Tillman, B W, Loosdrecht, A A van de, Pinedo, H M, Curiel, D T, Ossenkoppele, G J, Scheper, R J, de Gruijl, T D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394320/
https://www.ncbi.nlm.nih.gov/pubmed/14520439
http://dx.doi.org/10.1038/sj.bjc.6601225
_version_ 1782155388151398400
author Stam, A G M
Santegoets, S J A M
Westers, T M
Sombroek, C C
Janssen, J J W M
Tillman, B W
Loosdrecht, A A van de
Pinedo, H M
Curiel, D T
Ossenkoppele, G J
Scheper, R J
de Gruijl, T D
author_facet Stam, A G M
Santegoets, S J A M
Westers, T M
Sombroek, C C
Janssen, J J W M
Tillman, B W
Loosdrecht, A A van de
Pinedo, H M
Curiel, D T
Ossenkoppele, G J
Scheper, R J
de Gruijl, T D
author_sort Stam, A G M
collection PubMed
description Vaccination with autologous leukaemia-derived dendritic cells (DC) presents an adjuvant treatment option for chronic myeloid leukaemia (CML). Here, we show that high-efficiency CD40-targeted adenoviral gene transfer of GM-CSF to CML-derived DC induces long-lived maturation in the absence of exogenous cytokines and may thus ensure protracted stimulation of CML-specific T cells upon vaccination.
format Text
id pubmed-2394320
institution National Center for Biotechnology Information
language English
publishDate 2003
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23943202009-09-10 CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation Stam, A G M Santegoets, S J A M Westers, T M Sombroek, C C Janssen, J J W M Tillman, B W Loosdrecht, A A van de Pinedo, H M Curiel, D T Ossenkoppele, G J Scheper, R J de Gruijl, T D Br J Cancer Short Communication Vaccination with autologous leukaemia-derived dendritic cells (DC) presents an adjuvant treatment option for chronic myeloid leukaemia (CML). Here, we show that high-efficiency CD40-targeted adenoviral gene transfer of GM-CSF to CML-derived DC induces long-lived maturation in the absence of exogenous cytokines and may thus ensure protracted stimulation of CML-specific T cells upon vaccination. Nature Publishing Group 2003-10-06 2003-09-30 /pmc/articles/PMC2394320/ /pubmed/14520439 http://dx.doi.org/10.1038/sj.bjc.6601225 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Stam, A G M
Santegoets, S J A M
Westers, T M
Sombroek, C C
Janssen, J J W M
Tillman, B W
Loosdrecht, A A van de
Pinedo, H M
Curiel, D T
Ossenkoppele, G J
Scheper, R J
de Gruijl, T D
CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation
title CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation
title_full CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation
title_fullStr CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation
title_full_unstemmed CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation
title_short CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation
title_sort cd40-targeted adenoviral gm-csf gene transfer enhances and prolongs the maturation of human cml-derived dendritic cells upon cytokine deprivation
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394320/
https://www.ncbi.nlm.nih.gov/pubmed/14520439
http://dx.doi.org/10.1038/sj.bjc.6601225
work_keys_str_mv AT stamagm cd40targetedadenoviralgmcsfgenetransferenhancesandprolongsthematurationofhumancmlderiveddendriticcellsuponcytokinedeprivation
AT santegoetssjam cd40targetedadenoviralgmcsfgenetransferenhancesandprolongsthematurationofhumancmlderiveddendriticcellsuponcytokinedeprivation
AT westerstm cd40targetedadenoviralgmcsfgenetransferenhancesandprolongsthematurationofhumancmlderiveddendriticcellsuponcytokinedeprivation
AT sombroekcc cd40targetedadenoviralgmcsfgenetransferenhancesandprolongsthematurationofhumancmlderiveddendriticcellsuponcytokinedeprivation
AT janssenjjwm cd40targetedadenoviralgmcsfgenetransferenhancesandprolongsthematurationofhumancmlderiveddendriticcellsuponcytokinedeprivation
AT tillmanbw cd40targetedadenoviralgmcsfgenetransferenhancesandprolongsthematurationofhumancmlderiveddendriticcellsuponcytokinedeprivation
AT loosdrechtaavande cd40targetedadenoviralgmcsfgenetransferenhancesandprolongsthematurationofhumancmlderiveddendriticcellsuponcytokinedeprivation
AT pinedohm cd40targetedadenoviralgmcsfgenetransferenhancesandprolongsthematurationofhumancmlderiveddendriticcellsuponcytokinedeprivation
AT curieldt cd40targetedadenoviralgmcsfgenetransferenhancesandprolongsthematurationofhumancmlderiveddendriticcellsuponcytokinedeprivation
AT ossenkoppelegj cd40targetedadenoviralgmcsfgenetransferenhancesandprolongsthematurationofhumancmlderiveddendriticcellsuponcytokinedeprivation
AT scheperrj cd40targetedadenoviralgmcsfgenetransferenhancesandprolongsthematurationofhumancmlderiveddendriticcellsuponcytokinedeprivation
AT degruijltd cd40targetedadenoviralgmcsfgenetransferenhancesandprolongsthematurationofhumancmlderiveddendriticcellsuponcytokinedeprivation

Ejemplares similares