CD26/dipeptidyl peptidase IV enhances expression of topoisomerase II alpha and sensitivity to apoptosis induced by topoisomerase II inhibitors

CD26/dipeptidyl peptidase IV (DPPIV) is a cell surface-bound ectopeptidase with important roles in T-cell activation and tumour biology. We now report that CD26/DPPIV enhances sensitivity to apoptosis induced by the antineoplastic agents doxorubicin and etoposide. In particular, CD26/DPPIV presence...

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Detalles Bibliográficos
Autores principales: Sato, K, Aytac, U, Yamochi, T, Ohnuma, K, McKee, K S, Morimoto, C, Dang, N H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394325/
https://www.ncbi.nlm.nih.gov/pubmed/14520473
http://dx.doi.org/10.1038/sj.bjc.6601253

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