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Brostallicin (PNU-166196) – a new DNA minor groove binder that retains sensitivity in DNA mismatch repair-deficient tumour cells

Defects in DNA mismatch repair (MMR) are associated with a predisposition to tumorigenesis and with drug resistance owing to high mutation rates and failure to engage DNA-damage-induced apoptosis. DNA minor groove binders (MGBs) are a class of anticancer agents highly effective in a variety of human...

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Detalles Bibliográficos
Autores principales:	Fedier, A, Fowst, C, Tursi, J, Geroni, C, Haller, U, Marchini, S, Fink, D
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2003
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394335/ https://www.ncbi.nlm.nih.gov/pubmed/14562032 http://dx.doi.org/10.1038/sj.bjc.6601316

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