Both gene expression for orotate phosphoribosyltransferase and its ratio to dihydropyrimidine dehydrogenase influence outcome following fluoropyrimidine-based chemotherapy for metastatic colorectal cancer

Activation of 5-fluorouracil into its nucleotides requires phosphorylation by three pathways involving orotate phosphoribosyl-transferase (OPRT), uridine phosphorylase (UP), or thymidine phosphorylase (TP). In this study, we investigated the association between gene expressions of these three enzyme...

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Detalles Bibliográficos
Autores principales: Ichikawa, W, Uetake, H, Shirota, Y, Yamada, H, Takahashi, T, Nihei, Z, Sugihara, K, Sasaki, Y, Hirayama, R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394351/
https://www.ncbi.nlm.nih.gov/pubmed/14562021
http://dx.doi.org/10.1038/sj.bjc.6601335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394351/
https://www.ncbi.nlm.nih.gov/pubmed/14562021
http://dx.doi.org/10.1038/sj.bjc.6601335

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