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Both gene expression for orotate phosphoribosyltransferase and its ratio to dihydropyrimidine dehydrogenase influence outcome following fluoropyrimidine-based chemotherapy for metastatic colorectal cancer

Activation of 5-fluorouracil into its nucleotides requires phosphorylation by three pathways involving orotate phosphoribosyl-transferase (OPRT), uridine phosphorylase (UP), or thymidine phosphorylase (TP). In this study, we investigated the association between gene expressions of these three enzyme...

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Detalles Bibliográficos
Autores principales:	Ichikawa, W, Uetake, H, Shirota, Y, Yamada, H, Takahashi, T, Nihei, Z, Sugihara, K, Sasaki, Y, Hirayama, R
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2003
Materias:	Molecular and Cellular Pathology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394351/ https://www.ncbi.nlm.nih.gov/pubmed/14562021 http://dx.doi.org/10.1038/sj.bjc.6601335

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