CD1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer

Infiltrating CD1a(+) dendritic cells (DCs) have been associated with increased survival in a number of human cancers. This study investigated DC infiltration within breast cancers and the association with survival. Classical established prognostic factors, of tumour size, lymph node status, histolog...

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Autores principales: Coventry, B J, Morton, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394362/
https://www.ncbi.nlm.nih.gov/pubmed/12888826
http://dx.doi.org/10.1038/sj.bjc.6601114
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author Coventry, B J
Morton, J
author_facet Coventry, B J
Morton, J
author_sort Coventry, B J
collection PubMed
description Infiltrating CD1a(+) dendritic cells (DCs) have been associated with increased survival in a number of human cancers. This study investigated DC infiltration within breast cancers and the association with survival. Classical established prognostic factors, of tumour size, lymph node status, histological grade, lympho-vascular invasion, the KI-67 (MIB-1) fraction and the Nottingham Prognostic Index (NPI) were also compared. A total of 48 breast cancer patients were followed from the time of surgery and CD1a density analysis for 5 years or until death. Our data set validated previous studies, which show a relationship between survival and the NPI (P<0.001), tumour size (P<0.01) and lymph node status (P<0.05). Although more patients were alive at the 5-year time point in the group with higher CD1a DC density than the lower CD1a DC group, this failed to reach statistical significance at the P=0.05 level. Analysis at 10 years postsurgery is required to investigate the association further.
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spelling pubmed-23943622009-09-10 CD1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer Coventry, B J Morton, J Br J Cancer Molecular and Cellular Pathology Infiltrating CD1a(+) dendritic cells (DCs) have been associated with increased survival in a number of human cancers. This study investigated DC infiltration within breast cancers and the association with survival. Classical established prognostic factors, of tumour size, lymph node status, histological grade, lympho-vascular invasion, the KI-67 (MIB-1) fraction and the Nottingham Prognostic Index (NPI) were also compared. A total of 48 breast cancer patients were followed from the time of surgery and CD1a density analysis for 5 years or until death. Our data set validated previous studies, which show a relationship between survival and the NPI (P<0.001), tumour size (P<0.01) and lymph node status (P<0.05). Although more patients were alive at the 5-year time point in the group with higher CD1a DC density than the lower CD1a DC group, this failed to reach statistical significance at the P=0.05 level. Analysis at 10 years postsurgery is required to investigate the association further. Nature Publishing Group 2003-08-04 2003-07-29 /pmc/articles/PMC2394362/ /pubmed/12888826 http://dx.doi.org/10.1038/sj.bjc.6601114 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Coventry, B J
Morton, J
CD1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer
title CD1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer
title_full CD1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer
title_fullStr CD1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer
title_full_unstemmed CD1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer
title_short CD1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer
title_sort cd1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394362/
https://www.ncbi.nlm.nih.gov/pubmed/12888826
http://dx.doi.org/10.1038/sj.bjc.6601114
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