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Epidemiologic and molecular risk factors for contralateral breast cancer among young women

Women diagnosed with a first breast cancer before the age of 45 years have a greater than 5.0-fold risk of developing a second primary contralateral breast cancer (CBC) than women in the general population have of developing a first breast cancer. Identifying epidemiologic or molecular factors that...

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Autores principales: Li, C I, Malone, K E, Porter, P L, Daling, J R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394384/
https://www.ncbi.nlm.nih.gov/pubmed/12888823
http://dx.doi.org/10.1038/sj.bjc.6601042
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author Li, C I
Malone, K E
Porter, P L
Daling, J R
author_facet Li, C I
Malone, K E
Porter, P L
Daling, J R
author_sort Li, C I
collection PubMed
description Women diagnosed with a first breast cancer before the age of 45 years have a greater than 5.0-fold risk of developing a second primary contralateral breast cancer (CBC) than women in the general population have of developing a first breast cancer. Identifying epidemiologic or molecular factors that influence CBC risk could aid in the development of new strategies for the management of these patients. A total of 1285 participants in two case–control studies conducted in Seattle, Washington, who were 21–44 years of age when diagnosed with a first invasive breast carcinoma from 1983 to 1992, were followed through December 2001. Of them, 77 were diagnosed with CBC and 907 tumour tissues from first cancers were analysed. Women with body mass indices (BMIs) ⩾30 kg m(−2) had a 2.6-fold greater risk (95% CI: 1.1–5.9) of CBC compared to women with BMIs ⩽19.9 kg m(−2). Women whose first tumour was c-erbB-2 positive had a 1.7-fold (95% CI: 1.0–3.0) excess CBC risk. Body mass index and c-erbB-2 expression may be risk factors for CBC in young women. Further observational studies are needed to confirm these findings and to evaluate whether testing for c-erbB-2 in this population may help identify those at high risk for CBC.
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spelling pubmed-23943842009-09-10 Epidemiologic and molecular risk factors for contralateral breast cancer among young women Li, C I Malone, K E Porter, P L Daling, J R Br J Cancer Epidemiology Women diagnosed with a first breast cancer before the age of 45 years have a greater than 5.0-fold risk of developing a second primary contralateral breast cancer (CBC) than women in the general population have of developing a first breast cancer. Identifying epidemiologic or molecular factors that influence CBC risk could aid in the development of new strategies for the management of these patients. A total of 1285 participants in two case–control studies conducted in Seattle, Washington, who were 21–44 years of age when diagnosed with a first invasive breast carcinoma from 1983 to 1992, were followed through December 2001. Of them, 77 were diagnosed with CBC and 907 tumour tissues from first cancers were analysed. Women with body mass indices (BMIs) ⩾30 kg m(−2) had a 2.6-fold greater risk (95% CI: 1.1–5.9) of CBC compared to women with BMIs ⩽19.9 kg m(−2). Women whose first tumour was c-erbB-2 positive had a 1.7-fold (95% CI: 1.0–3.0) excess CBC risk. Body mass index and c-erbB-2 expression may be risk factors for CBC in young women. Further observational studies are needed to confirm these findings and to evaluate whether testing for c-erbB-2 in this population may help identify those at high risk for CBC. Nature Publishing Group 2003-08-04 2003-07-29 /pmc/articles/PMC2394384/ /pubmed/12888823 http://dx.doi.org/10.1038/sj.bjc.6601042 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Li, C I
Malone, K E
Porter, P L
Daling, J R
Epidemiologic and molecular risk factors for contralateral breast cancer among young women
title Epidemiologic and molecular risk factors for contralateral breast cancer among young women
title_full Epidemiologic and molecular risk factors for contralateral breast cancer among young women
title_fullStr Epidemiologic and molecular risk factors for contralateral breast cancer among young women
title_full_unstemmed Epidemiologic and molecular risk factors for contralateral breast cancer among young women
title_short Epidemiologic and molecular risk factors for contralateral breast cancer among young women
title_sort epidemiologic and molecular risk factors for contralateral breast cancer among young women
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394384/
https://www.ncbi.nlm.nih.gov/pubmed/12888823
http://dx.doi.org/10.1038/sj.bjc.6601042
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