Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin

A standardised, effective systemic therapy for metastatic neuroendocrine tumours (NETs) has not been established to date. We reviewed the management of 15 patients with inoperable, metastatic NET treated systematically with a combination chemotherapy regimen of infusional 5-fluorouracil, folinic aci...

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Autores principales: Gonzalez, M A, Biswas, S, Clifton, L, Corrie, P G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394387/
https://www.ncbi.nlm.nih.gov/pubmed/12888810
http://dx.doi.org/10.1038/sj.bjc.6601167
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author Gonzalez, M A
Biswas, S
Clifton, L
Corrie, P G
author_facet Gonzalez, M A
Biswas, S
Clifton, L
Corrie, P G
author_sort Gonzalez, M A
collection PubMed
description A standardised, effective systemic therapy for metastatic neuroendocrine tumours (NETs) has not been established to date. We reviewed the management of 15 patients with inoperable, metastatic NET treated systematically with a combination chemotherapy regimen of infusional 5-fluorouracil, folinic acid and streptozocin. Overall objective response rate was 53% and tolerability was excellent.
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spelling pubmed-23943872009-09-10 Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin Gonzalez, M A Biswas, S Clifton, L Corrie, P G Br J Cancer Clinical A standardised, effective systemic therapy for metastatic neuroendocrine tumours (NETs) has not been established to date. We reviewed the management of 15 patients with inoperable, metastatic NET treated systematically with a combination chemotherapy regimen of infusional 5-fluorouracil, folinic acid and streptozocin. Overall objective response rate was 53% and tolerability was excellent. Nature Publishing Group 2003-08-04 2003-07-29 /pmc/articles/PMC2394387/ /pubmed/12888810 http://dx.doi.org/10.1038/sj.bjc.6601167 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Clinical
Gonzalez, M A
Biswas, S
Clifton, L
Corrie, P G
Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin
title Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin
title_full Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin
title_fullStr Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin
title_full_unstemmed Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin
title_short Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin
title_sort treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin
topic Clinical
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394387/
https://www.ncbi.nlm.nih.gov/pubmed/12888810
http://dx.doi.org/10.1038/sj.bjc.6601167
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