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Ex vivo analysis of topotecan: advancing the application of laboratory-based clinical therapeutics
Topotecan is currently approved for relapsed small-cell lung cancer and ovarian cancer. Topotecan's efficacy in the second-line setting and novel mechanism of action suggest broad antitumour activity. We utilised a clinically validated, cell-death, ex vivo assay in human tumour explants to exam...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2003
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394409/ https://www.ncbi.nlm.nih.gov/pubmed/14583785 http://dx.doi.org/10.1038/sj.bjc.6601336 |