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c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis

The proto-oncogene c-Myc is overexpressed in 70% of colorectal tumours and can modulate proliferation and apoptosis after cytotoxic insult. Using an isogenic cell system, we demonstrate that c-Myc overexpression in colon carcinoma LoVo cells resulted in sensitisation to camptothecin-induced apoptosi...

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Detalles Bibliográficos
Autores principales:	Arango, D, Mariadason, J M, Wilson, A J, Yang, W, Corner, G A, Nicholas, C, Aranes, M J, Augenlicht, L H
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2003
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394410/ https://www.ncbi.nlm.nih.gov/pubmed/14583781 http://dx.doi.org/10.1038/sj.bjc.6601338

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