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CHEK2 variants associate with hereditary prostate cancer

Recently, variants in CHEK2 gene were shown to associate with sporadic prostate cancer in the USA. In the present study from Finland, we found that the frequency of 1100delC, a truncating variant that abrogates the kinase activity, was significantly elevated among 120 patients with hereditary prosta...

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Detalles Bibliográficos
Autores principales:	Seppälä, E H, Ikonen, T, Mononen, N, Autio, V, Rökman, A, Matikainen, M P, Tammela, T L J, Schleutker, J
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2003
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394451/ https://www.ncbi.nlm.nih.gov/pubmed/14612911 http://dx.doi.org/10.1038/sj.bjc.6601425

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