Cargando…

Role of MC1R variants in uveal melanoma

Variants of the melanocortin-1 receptor (MC1R) gene have been linked to sun-sensitive skin types and hair colour, and may independently play a role in susceptibility to cutaneous melanoma. To assess the role of MC1R variants in uveal melanoma, we have analysed a cohort of 350 patients for the change...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hearle, N, Humphreys, J, Damato, B E, Wort, R, Talaban, R, Wixey, J, Green, H, Easton, D F, Houlston, R S
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2003
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394456/ https://www.ncbi.nlm.nih.gov/pubmed/14612910 http://dx.doi.org/10.1038/sj.bjc.6601358

Ejemplares similares

Microarray comparative genomic hybridisation analysis of intraocular uveal melanomas identifies distinctive imbalances associated with loss of chromosome 3
por: Hughes, S, et al.
Publicado: (2005)

MC1R gene variants and non-melanoma skin cancer: a pooled-analysis from the M-SKIP project
por: Tagliabue, E, et al.
Publicado: (2015)

Mutation frequencies of GNAQ, GNA11, BAP1, SF3B1, EIF1AX and TERT in uveal melanoma: detection of an activating mutation in the TERT gene promoter in a single case of uveal melanoma
por: Dono, M, et al.
Publicado: (2014)

Comprehensive analysis of common mitochondrial DNA variants and colorectal cancer risk
por: Webb, E, et al.
Publicado: (2008)

TGFBR1 variants TGFBR1(*)6A and Int7G24A are not associated with an increased familial colorectal cancer risk
por: Skoglund Lundin, J, et al.
Publicado: (2009)

CHEK2 variants in susceptibility to breast cancer and evidence of retention of the wild type allele in tumours
por: Sodha, N, et al.
Publicado: (2002)

HPC2/ELAC2 polymorphisms and prostate cancer risk: analysis by age of onset of disease
por: Meitz, J C, et al.
Publicado: (2002)

The TERT variant rs2736100 is associated with colorectal cancer risk
por: Kinnersley, B, et al.
Publicado: (2012)

CASP8 variants D302H and −652 6N ins/del do not influence the risk of colorectal cancer in the United Kingdom population
por: Pittman, A M, et al.
Publicado: (2008)

Further observations on LKB1/STK11 status and cancer risk in Peutz–Jeghers syndrome
por: Lim, W, et al.
Publicado: (2003)

Melanoma prone families with CDK4 germline mutation: phenotypic profile and associations with MC1R variants
por: Puntervoll, Hanne Eknes, et al.
Publicado: (2013)

ATM polymorphisms as risk factors for prostate cancer development
por: Angèle, S, et al.
Publicado: (2004)

Thymidylate synthase polymorphisms, folate and B-vitamin intake, and risk of colorectal adenoma
por: Hubner, R A, et al.
Publicado: (2007)

NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma
por: Flockhart, R J, et al.
Publicado: (2009)

Search for inherited susceptibility to radiation-associated meningioma by genomewide SNP linkage disequilibrium mapping
por: Hosking, F J, et al.
Publicado: (2011)

Low penetrance susceptibility to glioma is caused by the TP53 variant rs78378222
por: Enciso-Mora, V, et al.
Publicado: (2013)

Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas
por: Barker, K T, et al.
Publicado: (2002)

Does ocular treatment of uveal melanoma influence survival?
por: Damato, B
Publicado: (2010)

Prognostic significance of folate metabolism polymorphisms for lung cancer
por: Matakidou, A, et al.
Publicado: (2007)

Autophagy-Related Long Non-coding RNA Signature as Indicators for the Prognosis of Uveal Melanoma
por: Cui, Yi, et al.
Publicado: (2021)

Linkage and association analysis of nevus density and the region containing the melanoma gene CDKN2A in UK twins
por: Barrett, J H, et al.
Publicado: (2003)

Integrative analyses of a mitophagy-related gene signature for predicting prognosis in patients with uveal melanoma
por: Cheng, Yanhua, et al.
Publicado: (2022)

Multiple epigenetic modification profiles reveal the tumor immune microenvironment and clinical outcomes of uveal melanoma
por: Nan, Xinshuai, et al.
Publicado: (2023)

A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants
por: Theodoratou, E, et al.
Publicado: (2010)

Rare BRAF mutations in melanoma patients: implications for molecular testing in clinical practice
por: Heinzerling, L, et al.
Publicado: (2013)

A physical analysis of the Y chromosome shows no additional deletions, other than Gr/Gr, associated with testicular germ cell tumour
por: Linger, R, et al.
Publicado: (2007)

Germline mutations of the INK4a-ARF gene in patients with suspected genetic predisposition to melanoma
por: Soufir, N, et al.
Publicado: (2004)

Strong reduction of AGO2 expression in melanoma and cellular consequences
por: Völler, D, et al.
Publicado: (2013)

Common genetic variants in the 9p21 region and their associations with multiple tumours
por: Gu, F, et al.
Publicado: (2013)

Tebentafusp: T Cell Redirection for the Treatment of Metastatic Uveal Melanoma
por: Damato, Bertil E., et al.
Publicado: (2019)

Prostate cancer in male BRCA1 and BRCA2 mutation carriers has a more aggressive phenotype
por: Mitra, A, et al.
Publicado: (2008)

Molecular variants of the ATM gene in Hodgkin's disease in children
por: Liberzon, E, et al.
Publicado: (2004)

GOLM1 is related to the inflammatory/immune nature of uveal melanoma and acts as a promising indicator for prognosis and immunotherapy response
por: Liang, Xin, et al.
Publicado: (2022)

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array
por: Saunders, Edward J, et al.
Publicado: (2016)

TERT promoter mutations in gliomas, genetic associations and clinico-pathological correlations
por: Labussière, M, et al.
Publicado: (2014)

ATM variants 7271T>G and IVS10-6T>G among women with unilateral and bilateral breast cancer
por: Bernstein, J L, et al.
Publicado: (2003)

MRI of Uveal Melanoma
por: Ferreira, Teresa A., et al.
Publicado: (2019)

XPD gene polymorphism and host characteristics in the association with cutaneous malignant melanoma risk
por: Baccarelli, A, et al.
Publicado: (2004)

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact
por: Chiasson, Melissa A, et al.
Publicado: (2020)

Polygenic susceptibility to prostate and breast cancer: implications for personalised screening
por: Pashayan, N, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_j34tf824l0b2qo44n1km8cmnb2