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Plasma concentrations of 5-fluorouracil and F-β-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil

The pharmacokinetics and pharmacodynamics of oral S-1, a dihydropyrimidine dehydrogenase (DPD) inhibitory fluoropyrimidine, were compared with those of protracted venous infusion (PVI) of 5-fluorouracil (5-FU). In all, 10 patients with gastric cancer received PVI of 5-FU at a dose of 250 mg m(−2) da...

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Detalles Bibliográficos
Autores principales:	Yamada, Y, Hamaguchi, T, Goto, M, Muro, K, Matsumura, Y, Shimada, Y, Shirao, K, Nagayama, S
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2003
Materias:	Clinical
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394492/ https://www.ncbi.nlm.nih.gov/pubmed/12942110 http://dx.doi.org/10.1038/sj.bjc.6601224

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