LongSAGE profiling of nine human embryonic stem cell lines

To facilitate discovery of novel human embryonic stem cell (ESC) transcripts, we generated 2.5 million LongSAGE tags from 9 human ESC lines. Analysis of this data revealed that ESCs express proportionately more RNA binding proteins compared with terminally differentiated cells, and identified novel...

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Detalles Bibliográficos
Autores principales: Hirst, Martin, Delaney, Allen, Rogers, Sean A, Schnerch, Angelique, Persaud, Deryck R, O'Connor, Michael D, Zeng, Thomas, Moksa, Michelle, Fichter, Keith, Mah, Diana, Go, Anne, Morin, Ryan D, Baross, Agnes, Zhao, Yongjun, Khattra, Jaswinder, Prabhu, Anna-Liisa, Pandoh, Pawan, McDonald, Helen, Asano, Jennifer, Dhalla, Noreen, Ma, Kevin, Lee, Stephanie, Ally, Adrian, Chahal, Neil, Menzies, Stephanie, Siddiqui, Asim, Holt, Robert, Jones, Steven, Gerhard, Daniela S, Thomson, James A, Eaves, Connie J, Marra, Marco A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394759/
https://www.ncbi.nlm.nih.gov/pubmed/17570852
http://dx.doi.org/10.1186/gb-2007-8-6-r113
Descripción
Sumario:To facilitate discovery of novel human embryonic stem cell (ESC) transcripts, we generated 2.5 million LongSAGE tags from 9 human ESC lines. Analysis of this data revealed that ESCs express proportionately more RNA binding proteins compared with terminally differentiated cells, and identified novel ESC transcripts, at least one of which may represent a marker of the pluripotent state.

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