High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae

We present an approach for identifying condition-specific regulatory modules by using separate units of gene expression profiles along with ChIP-chip and motif data from Saccharomyces cerevisiae. By investigating the unique and common features of the obtained condition-specific modules, we detected...

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Detalles Bibliográficos
Autores principales: Lee, Hun-Goo, Lee, Hyo-Soo, Jeon, Sang-Hoon, Chung, Tae-Hoon, Lim, Young-Sung, Huh, Won-Ki
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395236/
https://www.ncbi.nlm.nih.gov/pubmed/18171483
http://dx.doi.org/10.1186/gb-2008-9-1-r2
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author Lee, Hun-Goo
Lee, Hyo-Soo
Jeon, Sang-Hoon
Chung, Tae-Hoon
Lim, Young-Sung
Huh, Won-Ki
author_facet Lee, Hun-Goo
Lee, Hyo-Soo
Jeon, Sang-Hoon
Chung, Tae-Hoon
Lim, Young-Sung
Huh, Won-Ki
author_sort Lee, Hun-Goo
collection PubMed
description We present an approach for identifying condition-specific regulatory modules by using separate units of gene expression profiles along with ChIP-chip and motif data from Saccharomyces cerevisiae. By investigating the unique and common features of the obtained condition-specific modules, we detected several important properties of transcriptional network reorganization. Our approach reveals the functionally distinct coregulated submodules embedded in a coexpressed gene module and provides an effective method for identifying various condition-specific regulatory events at high resolution.
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spelling pubmed-23952362008-05-29 High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae Lee, Hun-Goo Lee, Hyo-Soo Jeon, Sang-Hoon Chung, Tae-Hoon Lim, Young-Sung Huh, Won-Ki Genome Biol Method We present an approach for identifying condition-specific regulatory modules by using separate units of gene expression profiles along with ChIP-chip and motif data from Saccharomyces cerevisiae. By investigating the unique and common features of the obtained condition-specific modules, we detected several important properties of transcriptional network reorganization. Our approach reveals the functionally distinct coregulated submodules embedded in a coexpressed gene module and provides an effective method for identifying various condition-specific regulatory events at high resolution. BioMed Central 2008-01-03 /pmc/articles/PMC2395236/ /pubmed/18171483 http://dx.doi.org/10.1186/gb-2008-9-1-r2 Text en Copyright © 2008 Lee et al.; licensee BioMed Central Ltd. https://creativecommons.org/licenses/by/2.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0 (https://creativecommons.org/licenses/by/2.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Method
Lee, Hun-Goo
Lee, Hyo-Soo
Jeon, Sang-Hoon
Chung, Tae-Hoon
Lim, Young-Sung
Huh, Won-Ki
High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae
title High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae
title_full High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae
title_fullStr High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae
title_full_unstemmed High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae
title_short High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae
title_sort high-resolution analysis of condition-specific regulatory modules in saccharomyces cerevisiae
topic Method
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395236/
https://www.ncbi.nlm.nih.gov/pubmed/18171483
http://dx.doi.org/10.1186/gb-2008-9-1-r2
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