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Primary Liposarcoma of the Mediastinum
Patient. A 62-year-old man presented with effort dyspnea, non-productive cough and weakness of 4 month duration. He had no findings on physical examination. Discussion. Chest X-ray revealed a large mass in the left anterior mediastinum. Computerized tomography of the chest showed a well-delineated h...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
1998
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395397/ https://www.ncbi.nlm.nih.gov/pubmed/18521256 http://dx.doi.org/10.1080/13577149877993 |
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author | Greif, Joel Marmor, Silvia Merimsky, Ofer Kovner, Felix Inbar, Moshe |
author_facet | Greif, Joel Marmor, Silvia Merimsky, Ofer Kovner, Felix Inbar, Moshe |
author_sort | Greif, Joel |
collection | PubMed |
description | Patient. A 62-year-old man presented with effort dyspnea, non-productive cough and weakness of 4 month duration. He had no findings on physical examination. Discussion. Chest X-ray revealed a large mass in the left anterior mediastinum. Computerized tomography of the chest showed a well-delineated homogeneous mediastinal mass with fat-equivalent density and a small pleural effusion. Fiberoptic bronchoscopy revealed narrowing of the left main bronchus, secondary to external compression. The bronchial mucosa was normal and brush cytology was negative. A CT-guided fine needle aspiration (FNA) of the mass yielded fragments of cells embedded in myxoid background material and closely packed atypical lipoblasts, compatible with liposarcoma. The patient underwent a left lateral thoracotomy and margibnal resection of the mass. The histopathological examination confirmed the diagnosis of mixed-type liposarcoma, consisted of myxoid and pleomorphic liposarcoma. Postoperative two-field radiation therapy was delivered to the mediastinum for a total midplane dose of 40 Gy. After a disease-free interval of 8 months the disease recurred in the mediastinum and pleura. Palliative chemotherapy achieved a short duration partial response but the patient succumbed to local recurrence 2 years after the diagnosis. |
format | Text |
id | pubmed-2395397 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1998 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-23953972008-06-02 Primary Liposarcoma of the Mediastinum Greif, Joel Marmor, Silvia Merimsky, Ofer Kovner, Felix Inbar, Moshe Sarcoma Research Article Patient. A 62-year-old man presented with effort dyspnea, non-productive cough and weakness of 4 month duration. He had no findings on physical examination. Discussion. Chest X-ray revealed a large mass in the left anterior mediastinum. Computerized tomography of the chest showed a well-delineated homogeneous mediastinal mass with fat-equivalent density and a small pleural effusion. Fiberoptic bronchoscopy revealed narrowing of the left main bronchus, secondary to external compression. The bronchial mucosa was normal and brush cytology was negative. A CT-guided fine needle aspiration (FNA) of the mass yielded fragments of cells embedded in myxoid background material and closely packed atypical lipoblasts, compatible with liposarcoma. The patient underwent a left lateral thoracotomy and margibnal resection of the mass. The histopathological examination confirmed the diagnosis of mixed-type liposarcoma, consisted of myxoid and pleomorphic liposarcoma. Postoperative two-field radiation therapy was delivered to the mediastinum for a total midplane dose of 40 Gy. After a disease-free interval of 8 months the disease recurred in the mediastinum and pleura. Palliative chemotherapy achieved a short duration partial response but the patient succumbed to local recurrence 2 years after the diagnosis. Hindawi Publishing Corporation 1998-12 /pmc/articles/PMC2395397/ /pubmed/18521256 http://dx.doi.org/10.1080/13577149877993 Text en Copyright © 1998 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Greif, Joel Marmor, Silvia Merimsky, Ofer Kovner, Felix Inbar, Moshe Primary Liposarcoma of the Mediastinum |
title | Primary Liposarcoma of the Mediastinum |
title_full | Primary Liposarcoma of the Mediastinum |
title_fullStr | Primary Liposarcoma of the Mediastinum |
title_full_unstemmed | Primary Liposarcoma of the Mediastinum |
title_short | Primary Liposarcoma of the Mediastinum |
title_sort | primary liposarcoma of the mediastinum |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395397/ https://www.ncbi.nlm.nih.gov/pubmed/18521256 http://dx.doi.org/10.1080/13577149877993 |
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