Oncogenic Osteomalacia as a Harbinger of Recurrent Osteosarcoma

Discussion. Oncogenic osteomalacia is a rare paraneoplastic syndrome of skeletal demineralization from renal phosphate loss. Patients with this disorder have the characteristic clinical, laboratory, and radiographic findings of hyperphosphaturic osteomalacia. Although the pathophysiology has not yet...

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Detalles Bibliográficos
Autores principales: Lamont, Elizabeth B., Cavaghan, Melissa K., Brockstein, Bruce E.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1999
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395412/
https://www.ncbi.nlm.nih.gov/pubmed/18521270
http://dx.doi.org/10.1080/13577149977712
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author Lamont, Elizabeth B.
Cavaghan, Melissa K.
Brockstein, Bruce E.
author_facet Lamont, Elizabeth B.
Cavaghan, Melissa K.
Brockstein, Bruce E.
author_sort Lamont, Elizabeth B.
collection PubMed
description Discussion. Oncogenic osteomalacia is a rare paraneoplastic syndrome of skeletal demineralization from renal phosphate loss. Patients with this disorder have the characteristic clinical, laboratory, and radiographic findings of hyperphosphaturic osteomalacia. Although the pathophysiology has not yet been clearly delineated, a humoral factor produced by the tumor is suspected to be the cause. Purpose. We report the first case of oncogenic osteomalacia that improved with chemotherapy, discuss this paraneoplastic syndrome, and review the medical literature regarding its etiology.
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spelling pubmed-23954122008-06-02 Oncogenic Osteomalacia as a Harbinger of Recurrent Osteosarcoma Lamont, Elizabeth B. Cavaghan, Melissa K. Brockstein, Bruce E. Sarcoma Research Article Discussion. Oncogenic osteomalacia is a rare paraneoplastic syndrome of skeletal demineralization from renal phosphate loss. Patients with this disorder have the characteristic clinical, laboratory, and radiographic findings of hyperphosphaturic osteomalacia. Although the pathophysiology has not yet been clearly delineated, a humoral factor produced by the tumor is suspected to be the cause. Purpose. We report the first case of oncogenic osteomalacia that improved with chemotherapy, discuss this paraneoplastic syndrome, and review the medical literature regarding its etiology. Hindawi Publishing Corporation 1999-09 /pmc/articles/PMC2395412/ /pubmed/18521270 http://dx.doi.org/10.1080/13577149977712 Text en Copyright © 1999 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lamont, Elizabeth B.
Cavaghan, Melissa K.
Brockstein, Bruce E.
Oncogenic Osteomalacia as a Harbinger of Recurrent Osteosarcoma
title Oncogenic Osteomalacia as a Harbinger of Recurrent Osteosarcoma
title_full Oncogenic Osteomalacia as a Harbinger of Recurrent Osteosarcoma
title_fullStr Oncogenic Osteomalacia as a Harbinger of Recurrent Osteosarcoma
title_full_unstemmed Oncogenic Osteomalacia as a Harbinger of Recurrent Osteosarcoma
title_short Oncogenic Osteomalacia as a Harbinger of Recurrent Osteosarcoma
title_sort oncogenic osteomalacia as a harbinger of recurrent osteosarcoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395412/
https://www.ncbi.nlm.nih.gov/pubmed/18521270
http://dx.doi.org/10.1080/13577149977712
work_keys_str_mv AT lamontelizabethb oncogenicosteomalaciaasaharbingerofrecurrentosteosarcoma
AT cavaghanmelissak oncogenicosteomalaciaasaharbingerofrecurrentosteosarcoma
AT brocksteinbrucee oncogenicosteomalaciaasaharbingerofrecurrentosteosarcoma

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